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Frankenberger, B. ; Schendel, D.J.

Third generation dendritic cell vaccines for tumor immunotherapy.

Eur. J. Cell Biol. 91, 53-58 (2012)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
This review summarizes our studies of the past several years on the development of third generation dendritic cell (DC) vaccines. These developments have implemented two major innovations in DC preparation: first, young DCs are prepared within 3days and, second, the DCs are matured with the help of Toll-like receptor agonists, imbuing them with the capacity to produce bioactive IL-12 (p70). Based on phenotype, chemokine-directed migration, facility to process and present antigens, and stimulatory capacity to polarize Th1 responses in CD4(+) T cells, induce antigen-specific CD8(+) CTL and activate natural killer cells, these young mDCs display all the important properties needed for initiating good antitumor responses in a vaccine setting.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Dendritic cells; Young dendritic cells; Dendritic cell-based vaccines; Antitumor response; Memory effector cytotoxic T lymphocytes; Dendritic cell maturation; Th1-polarization
ISSN (print) / ISBN 0171-9335
e-ISSN 1618-1298
Zeitschrift European Journal of Cell Biology
Quellenangaben Band: 91, Heft: 1, Seiten: 53-58 Artikelnummer: , Supplement: ,
Verlag Elsevier
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Molecular Immunology (IMI)