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Hvidtfeldt, U.A.* ; Taj, T.* ; Chen, J.* ; Rodopoulou, S.* ; Strak, M.* ; de Hoogh, K.* ; Andersen, Z.J.* ; Bellander, T.* ; Brandt, J.* ; Fecht, D.* ; Forastiere, F.* ; Gulliver, J.* ; Hertel, O.* ; Hoffmann, B.* ; Jørgensen, J.T.* ; Katsouyanni, K.* ; Ketzel, M.* ; Lager, A.* ; Leander, K.* ; Ljungman, P.* ; Magnusson, P.K.E.* ; Nagel, G.* ; Pershagen, G.* ; Rizzuto, D.* ; Samoli, E.* ; So, R.* ; Stafoggia, M.* ; Tjønneland, A.* ; Vermeulen, R.* ; Weinmayr, G.* ; Wolf, K. ; Zhang, J.* ; Zitt, E.* ; Brunekreef, B.* ; Hoek, G.* ; Raaschou-Nielsen, O.*

Long term exposure to air pollution and kidney parenchyma cancer – Effects of low-level air pollution: A Study in Europe (ELAPSE).

Environ. Res. 215:114385 (2022)
Postprint DOI PMC
Open Access Green
BACKGROUND: Particulate matter (PM) is classified as a group 1 human carcinogen. Previous experimental studies suggest that particles in diesel exhaust induce oxidative stress, inflammation and DNA damage in kidney cells, but the evidence from population studies linking air pollution to kidney cancer is limited. METHODS: We pooled six European cohorts (N = 302,493) to assess the association of residential exposure to fine particles (PM2.5), nitrogen dioxide (NO2), black carbon (BC), warm season ozone (O3) and eight elemental components of PM2.5 (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) with cancer of the kidney parenchyma. The main exposure model was developed for year 2010. We defined kidney parenchyma cancer according to the International Classification of Diseases 9th and 10th Revision codes 189.0 and C64. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. RESULTS: The participants were followed from baseline (1985–2005) to 2011–2015. A total of 847 cases occurred during 5,497,514 person-years of follow-up (average 18.2 years). Median (5–95%) exposure levels of NO2, PM2.5, BC and O3 were 24.1 μg/m3 (12.8–39.2), 15.3 μg/m3 (8.6–19.2), 1.6 10−5 m−1 (0.7–2.1), and 87.0 μg/m3 (70.3–97.4), respectively. The results of the fully adjusted linear analyses showed a hazard ratio (HR) of 1.03 (95% confidence interval [CI]: 0.92, 1.15) per 10 μg/m³ NO2, 1.04 (95% CI: 0.88, 1.21) per 5 μg/m³ PM2.5, 0.99 (95% CI: 0.89, 1.11) per 0.5 10−5 m−1 BCE, and 0.88 (95% CI: 0.76, 1.02) per 10 μg/m³ O3. We did not find associations between any of the elemental components of PM2.5 and cancer of the kidney parenchyma. CONCLUSION: We did not observe an association between long-term ambient air pollution exposure and incidence of kidney parenchyma cancer.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Air Pollution ; Kidney Cancer Incidence ; Nitrogen Dioxide ; Ozone ; Particulate Matter ; Pm Elemental Components
Sprache englisch
Veröffentlichungsjahr 2022
HGF-Berichtsjahr 2022
ISSN (print) / ISBN 0013-9351
e-ISSN 1096-0953
Zeitschrift Environmental Research
Quellenangaben Band: 215, Heft: , Seiten: , Artikelnummer: 114385 Supplement: ,
Verlag Elsevier
Verlagsort San Diego, Calif.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504000-001
Förderungen Health Effects Institute (HEI)
United States Environmental Protection Agency (EPA)
DOI 10.1016/j.envres.2022.114385
WOS ID WOS:000877325400009
Scopus ID 85138810938
PubMed ID 36154858
Erfassungsdatum 2022-10-12
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