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Marttila, S.* ; Tamminen, H.* ; Rajić, S.* ; Mishra, P.P.* ; Lehtimäki, T.* ; Raitakari, O.* ; Kähönen, M.* ; Kananen, L.* ; Jylhävä, J.* ; Hägg, S.* ; Delerue, T. ; Peters, A. ; Waldenberger, M. ; Kleber, M.E.* ; März, W.* ; Luoto, R.* ; Raitanen, J.* ; Sillanpää, E.* ; Laakkonen, E.K.* ; Heikkinen, A.* ; Ollikainen, M.* ; Raitoharju, E.*

Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues.

Epigenomics 14, 1105-1124 (2022)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Aims & methods: The aim of this study was to characterize the methylation level of a polymorphically imprinted gene, VTRNA2-1/nc886, in human populations and somatic tissues.48 datasets, consisting of more than 30 tissues and >30,000 individuals, were used. Results: nc886 methylation status is associated with twin status and ethnic background, but the variation between populations is limited. Monozygotic twin pairs present concordant methylation, whereas ∼30% of dizygotic twin pairs present discordant methylation in the nc886 locus. The methylation levels of nc886 are uniform across somatic tissues, except in cerebellum and skeletal muscle. Conclusion: The nc886 imprint may be established in the oocyte, and, after implantation, the methylation status is stable, excluding a few specific tissues.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Dna Methylation ; Vtrna2-1 ; Developmental Origins Of Health And Disease Hypothesis ; Imprinting ; Metastable Epiallele ; Nc886 ; Noncoding 886 ; Polymorphic Imprinting ; Population Studies; KORA, Diabetes/ Metabolisches Syndrom, Epigenetik
ISSN (print) / ISBN 1750-1911
e-ISSN 1750-192X
Zeitschrift Epigenomics
Quellenangaben Band: 14, Heft: 18, Seiten: 1105-1124 Artikelnummer: , Supplement: ,
Verlag Future Medicine
Verlagsort London
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology II (EPI2)
Förderungen Juho Vainio Foundation
Paivikki and Sakari Sohlberg Foundation
Laboratoriolääketieteen edistämissäätiö sr
Signe ja Ane Gyllenbergin Säätiö
the Sigrid Juselius Foundation
Pirkanmaa Regional Fund of Finnish Cultural Foundation
Karolinska Institutet Strategic Research Program in Epidemiology