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Jolesch, A. ; Elmer, K. ; Bendz, H. ; Issels, R.D. ; Nößner, E.

Hsp70, a messenger from hyperthermia for the immune system.

Eur. J. Cell Biol. 91, 48-52 (2012)
Postprint DOI PMC
Open Access Green
Heat shock proteins (Hsps) hold a dual role depending on their location. Inside cells, they fulfill essential survival functions as molecular chaperones forming complexes with intracellular polypeptides (self or foreign) to help in protein folding, the resolution of protein aggregates and intracellular protein transport. Released from the cell, they act as messengers communicating the cells' interior protein composition to the immune system for initiation of immune responses against intracellular proteins. Here we describe the mechanisms by which Hsp70, the heat-inducible Hsp70 family member, crosstalks with the immune system. Further, we discuss that clinical hyperthermia could be a way to initiate the immunologic activity of Hsp70 by upregulating its expression and facilitating release through local necrosis.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Heat shock protein 70; Hyperthermia; NK cells; Hsp70-specific CD4 T cells; IL-10; Crosspresentation
ISSN (print) / ISBN 0171-9335
e-ISSN 1618-1298
Zeitschrift European Journal of Cell Biology
Quellenangaben Band: 91, Heft: 1, Seiten: 48-52 Artikelnummer: , Supplement: ,
Verlag Elsevier
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Molecular Immunology (IMI)
CCG Tumor Therapy with Hyperthermia (IMI-KTH)