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Lowe, D.* ; Roy, L.* ; Tabocchini, M.A.* ; Rühm, W. ; Wakeford, R.* ; Woloschak, G.E.* ; Laurier, D.*

Radiation dose rate effects: What is new and what is needed?

Radiat. Environ. Biophys. 61, 507-543 (2022)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Despite decades of research to understand the biological effects of ionising radiation, there is still much uncertainty over the role of dose rate. Motivated by a virtual workshop on the "Effects of spatial and temporal variation in dose delivery" organised in November 2020 by the Multidisciplinary Low Dose Initiative (MELODI), here, we review studies to date exploring dose rate effects, highlighting significant findings, recent advances and to provide perspective and recommendations for requirements and direction of future work. A comprehensive range of studies is considered, including molecular, cellular, animal, and human studies, with a focus on low linear-energy-transfer radiation exposure. Limits and advantages of each type of study are discussed, and a focus is made on future research needs.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Dose Rate ; Epidemiology ; Ionising Radiation ; Low-let ; Radiobiology ; Recommendations
Sprache englisch
Veröffentlichungsjahr 2022
HGF-Berichtsjahr 2022
ISSN (print) / ISBN 0301-634X
e-ISSN 1432-2099
Zeitschrift Radiation and Environmental Biophysics
Quellenangaben Band: 61, Heft: 4, Seiten: 507-543 Artikelnummer: , Supplement: ,
Verlag Springer
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Medicine (IRM)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Radiation Sciences
PSP-Element(e) G-501391-001
DOI 10.1007/s00411-022-00996-0
WOS ID WOS:000873426000001
Scopus ID 85140085662
PubMed ID 36241855
Erfassungsdatum 2022-11-25
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