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Vogelezang, S.* ; Bradfield, J.P.* ; Grant, S.F.A.* ; Felix, J.F.* ; Jaddoe, V.W.V.* ; Early Growth Genetics Consortium (Standl, M. ; Heinrich, J. ; Thiering, E. ; Waldenberger, M. ; Panoutsopoulou, K. ; Zeggini, E.)

Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes.

BMC Med. Genomics 15:124 (2022)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
BACKGROUND: Head circumference is associated with intelligence and tracks from childhood into adulthood. METHODS: We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age. RESULTS: Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes. CONCLUSIONS: The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Genetic Correlations ; Genome-wide Association Study ; Head Circumference ; Infancy
e-ISSN 1755-8794
Zeitschrift BMC Medical Genomics
Quellenangaben Band: 15, Heft: 1, Seiten: , Artikelnummer: 124 Supplement: ,
Verlag BioMed Central
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
Institute of Epidemiology II (EPI2)
Institute of Translational Genomics (ITG)
Förderungen NIDDK NIH HHS
NICHD NIH HHS
Wellcome Trust