Optoacoustic imaging offers a unique combination of observation volume and achievable resolution in vivo. However, the use of transgene labeling agents has been impractical because their signal is low compared to the background of the tissue. Thus, detection was limited to large numbers of cells. We tackle this problem by using switchable agents — switching creates a signal modulation which allows to separate the labeled cells from the constant background — making it virtually invisible.
FörderungenDeutsche Forschungsgemeinschaft Innovationsprogramms Horizon 2020 der Europäischen Union unter der Finanzhilfevereinbarung Europäischen Forschungsrat Arbeitsgruppe Cell Engineering werden gefördert durch die Deutsche Forschungsgemeinschaft