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Krieg, S.M.* ; Bernhard, D.* ; Ille, S.* ; Meyer, B.* ; Combs, S.E. ; Rotenberg, A.* ; Frühwald, M.C.*

Neurosurgery for eloquent lesions in children: State-of-the-art rationale and technical implications of perioperative neurophysiology.

Neurosurg. Focus 53:E4 (2022)
Verlagsversion Forschungsdaten DOI PMC
OBJECTIVE: In adult patients, an increasing group of neurosurgeons specialize entirely in the treatment of highly eloquent tumors, particularly gliomas. In contrast, extensive perioperative neurophysiological workup for pediatric cases has been limited essentially to epilepsy surgery. METHODS: The authors discuss radio-oncological and general oncological considerations based on the current literature and their personal experience. RESULTS: While several functional mapping modalities facilitate preoperative identification of cortically and subcortically located eloquent areas, not all are suited for children. Direct cortical intraoperative stimulation is impractical in many young patients due to the reduced excitability of the immature cortex. Behavioral requirements also limit the utility of functional MRI and magnetoencephalography in children. In contrast, MRI-derived tractography and navigated transcranial magnetic stimulation are available across ages. Herein, the authors review the oncological rationale of function-guided resection in pediatric gliomas including technical implications such as personalized perioperative neurophysiology, surgical strategies, and limitations. CONCLUSIONS: Taken together, these techniques, despite the limitations of some, facilitate the identification of eloquent areas prior to tumor surgery and radiotherapy as well as during follow-up of residual tumors.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Epilepsy Surgery ; Glioma ; Language ; Motor ; Neuromonitoring ; Neurophysiology ; Preoperative Mapping; Transcranial Magnetic Stimulation; Brain-tumor Surgery; Cortical Stimulation; Motor; Improves; Plasticity; Resection; Adult
ISSN (print) / ISBN 1092-0684
e-ISSN 1092-0684
Zeitschrift Neurosurgical Focus
Quellenangaben Band: 53, Heft: 6, Seiten: , Artikelnummer: E4 Supplement: ,
Verlag American Association of Neurological Surgeons
Verlagsort 5550 Meadowbrook Drive, Rolling Meadows, Il 60008 Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Medicine (IRM)