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Klymenko, S.V.* ; Smida, J. ; Atkinson, M.J. ; Bebeshko, V.G.* ; Nathrath, M. ; Rosemann, M.

Allelic imbalances in radiation-associated acute myeloid leukemia.

Genes 2, 384-393 (2011)
Verlagsversion Volltext DOI
Open Access Gold
Creative Commons Lizenzvertrag
Acute myeloid leukemia (AML) can develop as a secondary malignancy following radiotherapy, but also following low-dose environmental or occupational radiation exposure. Therapy-related AML frequently carries deletions of chromosome 5q and/or 7, but for low-dose exposure associated AML this has not been described. For the present study we performed genome-wide screens for loss-of-heterozygosity (LOH) in a set of 19 AML cases that developed after radiation-exposure following the Chernobyl accident. Using Affymetrix SNP arrays we found large regions of LOH in 16 of the cases. Eight cases (42%) demonstrated LOH at 5q and/or 7, which is a known marker of complex karyotypic changes and poor prognosis. We could show here for the first time that exposure to low-dose ionizing radiation induces AML with molecular alterations similar to those seen in therapy-related cases.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter acute myeloid leukemia; ionizing radiation; Chernobyl accident; single nucleotide polymorphism; microarray
ISSN (print) / ISBN 2073-4425
e-ISSN 2073-4425
Zeitschrift Genes
Quellenangaben Band: 2, Heft: 2, Seiten: 384-393 Artikelnummer: , Supplement: ,
Verlag MDPI
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Biology (ISB)
CCG Osteosarcoma (PATH-KOS)