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Raj, T. ; Negraschus, A.* ; Heissmeyer, V.

Roquin-dependent gene regulation in immune-mediated diseases and future therapies.

Int. Immunol. 35, 159-170 (2022)
Postprint DOI PMC
Open Access Green
The RNA-binding proteins Roquin-1/2 and Regnase-1 exert essential regulation by controlling proinflammatory mRNA expression to prevent autoimmune disease. More recently, inhibition of this post-transcriptional gene regulatory program has been demonstrated to enable enhanced anti-tumor responses by tumor antigen-specific CD8 + T cells. In this review we describe the functions of these RNA-binding proteins and the phenotypes that arise in association with genetic inhibition or inactivation. We discuss how inducible inactivation of the system reprograms CD4 + and CD8 + T cell fates by changing cell metabolism, activation, differentiation or effector/memory decisions. We furthermore outline what we need to know to precisely modulate this system in order to dampen autoimmune reactions or boost the efficacy of adoptively transferred T cells or chimeric antigen receptor (CAR) T cells in cancer immunotherapies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Regnase-1 ; Autoimmunity ; Autoinflammation ; Cancer Therapy ; Post-transcriptional Gene Regulation
Sprache englisch
Veröffentlichungsjahr 2022
HGF-Berichtsjahr 2022
ISSN (print) / ISBN 0953-8178
e-ISSN 1460-2377
Zeitschrift International Immunology
Quellenangaben Band: 35, Heft: 4, Seiten: 159-170 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Molecular Immune Regulation (AMIR)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Immune Response and Infection
PSP-Element(e) G-501712-001
DOI 10.1093/intimm/dxac059
Scopus ID 85160242165
PubMed ID 36525589
Erfassungsdatum 2022-12-20
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