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Babamiri, A.* ; Ahookhosh, K.* ; Abdollahi, H.* ; Taheri, M.H.* ; Cui, X.* ; Nabaei, M.* ; Farnoud, A.

Effect of laryngeal jet on dry powder inhaler aerosol deposition: A numerical simulation.

Comp. meth. biomech. biomed. engin. imag. visual., DOI: 10.1080/10255842.2022.2152280 (2022)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Although pulmonary drug delivery has been deeply investigated, the effect of the laryngeal jet on particle deposition during drug delivery with dry powder inhalers (DPI) has not been evaluated profoundly. In this study, the flow structure and particle deposition pattern of a DPI in two airway models, one with mouth-throat region including the larynx and the other one without it, are numerically investigated. The results revealed that the laryngeal jet has a considerable effect on particle deposition. The presence of laryngeal jet leads to 4-fold and 2-fold higher deposition efficiencies for inlet flow rates of 30 and 90 L/min, respectively.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Cfd ; Laryngeal Jet ; Pulmonary Drug Delivery ; Flow Structure ; Particle Deposition Pattern
ISSN (print) / ISBN 2168-1163
e-ISSN 2168-1171
Zeitschrift Computer methods in biomechanics and biomedical engineering : imaging & visualization
Verlag Taylor & Francis
Verlagsort Abingdon
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Computational Biology (ICB)