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Ruiz Ojeda, F.J. ; Anguita-Ruiz, A.* ; Rico, M.C.* ; Leis, R.* ; Bueno, G.* ; Moreno, L.A.* ; Gil-Campos, M.* ; Gil, Á.* ; Aguilera, C.M.*

Serum levels of the novel adipokine isthmin-1 are associated with obesity in pubertal boys.

World J. Pediatr. 19, 864-872 (2023)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
OBJECTIVES: To evaluate whether there is an association between the serum levels of the novel insulin-like adipokine isthmin-1 (ISM1) and obesity-related phenotypes in a population of Spanish children and to investigate the plausible molecular alterations behind the alteration of the serum levels of this protein in children with obesity. METHODS: The study population is a sub-cohort of the PUBMEP research project, consisting of a cross-sectional population of 119 pubertal children with overweight (17 boys, 19 girls), obesity (20 boys, 25 girls), and normal weight (17 boys, 21 girls). All subjects were classified into experimental groups according to their sex, obesity, and insulin resistance (IR) status. They were counted anthropometry, glucose and lipid metabolism, inflammation and cardiovascular biomarkers as well as isthmin-1 (ISM1) serum levels. This population was intended as a discovery population to elucidate the relationship between obesity and ISM1 levels in children. Furthermore, the study population had blood whole-genome DNA methylation examined, allowing deepening into the obesity-ISM1 molecular relationship. RESULTS: Higher serum ISM1 levels were observed in boys with obesity than in normal weight (P = 0.004) and overweight (P = 0.007) boys. ISM1 serum levels were positively associated with body mass index (BMI) Z-score (P = 0.005) and fat mass (P = 0.058) and negatively associated with myeloperoxidase (MPO) (P = 0.043) in boys. Although we did not find associations between ISM1 serum levels and metabolic outcomes in girls, which may indicate a putative sexual dimorphism, fat mass was positively associated in all children, including boys and girls (P = 0.011). DNA methylation levels in two-enhancer-related CpG sites of ISM1 (cg03304641 and cg14269097) were associated with serum levels of ISM1 in children. CONCLUSIONS: ISM1 is associated with obesity in boys at the pubertal stage, elucidating how this protein might be of special relevance as a new biomarker of obesity in children. Further studies including a longitudinal design during puberty are needed.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Children ; Epigenetics ; Isthmin-1 ; Obesity ; Puberty; Diet-induced Obesity; Insulin-resistance; Cardiovascular Risk; Myeloperoxidase; Leptin; Inflammation; Children; Health
ISSN (print) / ISBN 1708-8569
e-ISSN 1867-0687
Zeitschrift World Journal of Pediatrics
Quellenangaben Band: 19, Heft: 9, Seiten: 864-872 Artikelnummer: , Supplement: ,
Verlag Zhejiang Univ Press
Verlagsort Xixi Campus, Zhejiang University, No. 148 Tianmushan Road, Hangzhou, Zhejiang, Peoples R China
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
Förderungen Mapfre Foundation
Redes tematicas de Investigacion cooperativa RETIC
Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica (I + D + I), Instituto de Salud Carlos III-Health Research Funding (FONDOS FEDER)
Universidad de Granada/CBUA