Startseite
English
Erweiterte Suche
Durchblättern nach ...
Publikationen im Überblick
Ansprechpartner
Hilfe
DOI
PMC
 |
|
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Modulation of Fgfr1a signaling in zebrafish reveals a genetic basis for the aggression-boldness syndrome.
J. Neurosci. 31, 13796-13807 (2011)
Behavioral syndromes are suites of two or more behaviors that correlate across environmental contexts. The aggression-boldness syndrome links aggression, boldness, and exploratory activity in a novel environment. Although aggression-boldness has been described in many animals, the mechanism linking its behavioral components is not known. Here we show that mutation of the gene encoding fibroblast growth factor receptor 1a (fgfr1a) simultaneously increases aggression, boldness, and exploration in adult zebrafish. We demonstrate that altered Fgf signaling also results in reduced brain histamine levels in mutants. Pharmacological increase of histamine signaling is sufficient to rescue the behavioral phenotype of fgfr1a mutants. Together, we show that a single genetic locus can underlie the aggression-boldness behavioral syndrome. We also identify one of the neurotransmitter pathways that may mediate clustering of these behaviors.
Altmetric
Weitere Metriken?
Zusatzinfos bearbeiten
[➜Einloggen]
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
histamine h-3 receptor; fish danio-rerio; behavioral syndromes; gasterosteus-aculeatus; 3-spined stickleback; therapeutic target; betta-splendens; brain; expression; system
ISSN (print) / ISBN
0270-6474
e-ISSN
1529-2401
Zeitschrift
Journal of Neuroscience
Quellenangaben
Band: 31,
Heft: 39,
Seiten: 13796-13807
Verlag
Society for Neuroscience
Verlagsort
Washington, DC, USA
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed