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Hoene, M.* ; Zhao, X.* ; Machann, J. ; Birkenfeld, A.L. ; Heni, M. ; Peter, A. ; Niess, A.* ; Moller, A. ; Lehmann, R. ; Xu, G.* ; Weigert, C.

Exercise-induced N-lactoylphenylalanine predicts adipose tissue loss during endurance training in overweight and obese humans.

Metabolites 13:15 (2022)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Physical exercise is a powerful measure to prevent cardiometabolic diseases. However, the individual response to lifestyle interventions is variable and cannot, to date, be predicted. N-Lactoylphenylalanine (Lac-Phe) produced during exercise has recently been shown to mediate weight loss in obese mice. Lac-Phe could also contribute to, and potentially explain differences in, the effectiveness of exercise interventions in humans. Sedentary overweight and obese subjects completed an 8-week supervised endurance exercise intervention (n = 22). Before and after the intervention, plasma levels of Lac-Phe were determined by UHPLC-MS in the resting state and immediately after an acute bout of endurance exercise. Adipose tissue volume was quantified using MRI. Acute exercise caused a pronounced increase in Lac-Phe, both before and after the intervention. Higher levels of Lac-Phe after acute exercise were associated with a greater reduction in abdominal subcutaneous and, to a lower degree, visceral adipose tissue during the intervention. Lac-Phe produced during physical activity could contribute to weight loss by acting as a signaling molecule that regulates food intake, as previously shown in mice. Quantification of Lac-Phe during an exercise test could be employed as a tool to predict and potentially improve the individual response to exercise-based lifestyle interventions in overweight humans and those with obesity.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter N-lactoylphenylalanine (lac-phe) ; Biomarker ; Exercise Intervention ; Exerkine ; Obesity; Lactate
ISSN (print) / ISBN 2218-1989
e-ISSN 2218-1989
Zeitschrift Metabolites
Quellenangaben Band: 13, Heft: 1, Seiten: , Artikelnummer: 15 Supplement: ,
Verlag MDPI
Verlagsort St Alban-anlage 66, Ch-4052 Basel, Switzerland
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
Förderungen Open Access Publishing Fund of the University of Tubingen
University of Tubingen
German Diabetes Association
German Federal Ministry of Education and Research (BMBF) (DZD e.V.)
National Natural Science Foundation of China
Sino-German Center for Research Promotion