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Ott, R. ; Achenbach, P. ; Ewald, D.A.* ; Friedl, N. ; Gemulla, G.* ; Hubmann, M.* ; Kordonouri, O.* ; Loff, A.* ; Marquardt, E.* ; Sifft, P. ; Sporreiter, M.S. ; Zapardiel-Gonzalo, J. ; Ziegler, A.-G.

SARS-CoV-2 seroprevalence in preschool and school-age children.

Dtsch. Arztebl. Int. 119, 765-770 (2022)
Verlagsversion DOI PMC
Free journal
BACKGROUND: The SARS-CoV-2 pandemic is ongoing in Germany. Children and adolescents are increasingly being infected, and many cases presumably remain undetected and unreported. Sero-epidemiological studies can help estimate the true number of infections. METHODS: From January 2020 to June 2022, 59 786 persons aged 1-17 years were tested for SARS-CoV-2 antibodies as part of a screening program for presymptomatic type 1 diabetes in the German federal state of Bavaria (the Fr1da study). RESULTS: In June 2022, the seroprevalence in the overall population was 73.5%. The seroprevalence was significantly higher in school-age children (from 5 to 10 years of age) than in preschool children (ages 1-4): 84.4% vs. 66.6%, p <0.001. In contrast, in November 2021, before the appearance of the omicron variant, the overall seroprevalence was 14.7% (16.2% of school-age children, 13.0% of preschool children, p = 0.06). In the overall collective, seroprevalence increased fivefold from the fall of 2021 to June 2022 (by a factor of 5.2 in school-age children and 5.1 in preschool children). Similar seroprevalences, with smaller case numbers, were observed in June 2022 in the corresponding Fr1da studies in Saxony and Northern Germany: 87.8% and 76.7%, respectively. CONCLUSION: Monthly case counts reveal a substantial rise in SARS-CoV-2-infections among children and adolescents from late 2021 to mid-2022. The high percentage of preschool and school-age children who have been infected with SARS-CoV-2, in a population that has low vaccination coverage, should be taken into account in the development of health policies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
ISSN (print) / ISBN 1866-0452
e-ISSN 1866-0452
Zeitschrift Deutsches Ärzteblatt international
Quellenangaben Band: 119, Heft: 45, Seiten: 765-770 Artikelnummer: , Supplement: ,
Verlag Dt. Ärzte-Verl.
Verlagsort Dieselstrabe 2, Postfach 400265, D-50859 Cologne, Germany
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research Type 1 (IDF)
Förderungen Helmsley Charitable Trust
JDRF
LifeScience Foundation (LifeScience-Stiftung)
German Center for Diabetes Research (DZD)
German Federal Ministry of Education and Research