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Fasoula, N.-A. ; Karlas, A. ; Prokopchuk, O.* ; Katsouli, N. ; Bariotakis, M. ; Liapis, E. ; Götz, A. ; Kallmayer, M.* ; Reber, J. ; Novotny, A.* ; Friess, H.* ; Ringelhan, M.* ; Schmid, R.* ; Eckstein, H.H.* ; Hofmann, S.M. ; Ntziachristos, V.

Non-invasive multispectral optoacoustic tomography resolves intrahepatic lipids in patients with hepatic steatosis.

Photoacoustics 29:100454 (2023)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Hepatic steatosis is characterized by intrahepatic lipid accumulation and may lead to irreversible liver damage if untreated. Here, we investigate whether multispectral optoacoustic tomography (MSOT) can offer label-free detection of liver lipid content to enable non-invasive characterization of hepatic steatosis by analyzing the spectral region around 930 nm, where lipids characteristically absorb. In a pilot study, we apply MSOT to measure liver and surrounding tissues in five patients with liver steatosis and five healthy volunteers, revealing significantly higher absorptions at 930 nm in the patients, while no significant difference was observed in the subcutaneous adipose tissue of the two groups. We further corroborated the human observations with corresponding MSOT measurements in high fat diet (HFD) - and regular chow diet (CD)-fed mice. This study introduces MSOT as a potential non-invasive and portable technique for detecting/monitoring hepatic steatosis in clinical settings, providing justification for larger studies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Lipid Imaging ; Metabolism ; Molecular Imaging ; Msot ; Nafld ; Non-alcoholic Fatty Liver Disease ; Photoacoustics; Fatty Liver-disease; Diagnosis; Biopsy; Association
ISSN (print) / ISBN 2213-5979
Zeitschrift Photoacoustics
Quellenangaben Band: 29, Heft: , Seiten: , Artikelnummer: 100454 Supplement: ,
Verlag Elsevier
Verlagsort Hackerbrucke 6, 80335 Munich, Germany
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)
Institute of Diabetes and Regeneration Research (IDR)
Förderungen German Center of Infection Research (DZIF)
Helmholtz Zentrum Muenchen
DZHK (German Centre for Cardiovascular Research)
European Research Council (ERC)