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Doryab, A. ; Groll, J.*

Biomimetic in vitro lung models: Current challenges and future perspective.

Adv. Mater. 35:e2210519 (2023)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
As post-COVID complications, chronic respiratory diseases are one of the foremost causes of mortality. The quest for a cure for this recent global challenge underlines that the lack of predictive in vitro lung models is one of the main bottlenecks in pulmonary preclinical drug development. Despite rigorous efforts to develop biomimetic in vitro lung models, the current cutting-edge models represent a compromise in numerous technological and biological aspects. Most advanced in vitro models are still in the “proof-of-concept” phase with a low clinical translation of the findings. On the other hand, advances in cellular and molecular studies are mainly based on relatively simple and unrealistic in vitro models. Herein, the current challenges and potential strategies toward not only bioinspired but truly biomimetic lung models are discussed.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Additive Manufacturing ; Basement Membranes ; In Vitro Lung Models ; Lung-on-chip ; Scaffold Design; Barrier; Influenza; Disease; System; Airway
ISSN (print) / ISBN 0935-9648
e-ISSN 1521-4095
Zeitschrift Advanced materials
Quellenangaben Band: 35, Heft: 13, Seiten: , Artikelnummer: e2210519 Supplement: ,
Verlag Wiley
Verlagsort Weinheim
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Lung Health and Immunity (LHI)
Förderungen German Federal Ministry of Education and Research (BMBF)