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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Processing of carbon-reinforced construction materials releases PM2.5 inducing inflammation and (secondary) genotoxicity in human lung epithelial cells and fibroblasts.
Environ. Toxicol. Pharmacol. 98:104079 (2023)
Building demolition following domestic fires or abrasive processing after thermal recycling can release particles harmful for the environment and human health. To mimic such situations, particles release during dry-cutting of construction materials was investigated. A reinforcement material consisting of carbon rods (CR), carbon concrete composite (C³) and thermally treated C³ (ttC³) were physicochemically and toxicologically analyzed in monocultured lung epithelial cells, and co-cultured lung epithelial cells and fibroblasts at the air-liquid interface. C³ particles reduced their diameter to WHO fibre dimensions during thermal treatment. Caused by physical properties or by polycyclic aromatic hydrocarbons and bisphenol A found in the materials, especially the released particles of CR and ttC³ induced an acute inflammatory response and (secondary) DNA damage. Transcriptome analysis indicated that CR and ttC³ particles carried out their toxicity via different mechanisms. While ttC³ affected pro-fibrotic pathways, CR was mostly involved in DNA damage response and in pro-oncogenic signaling.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Air-liquid Interface ; Bisphenol A ; Carbon Fibre Toxicity ; Polycyclic Aromatic Hydrocarbons ; Transcriptome; Oxidative Stress; Bisphenol-a; Dna-damage; Exposure; Metabolism; Toxicity; Power; Pahs
ISSN (print) / ISBN
1382-6689
e-ISSN
1872-7077
Zeitschrift
Environmental Toxicology and Pharmacology
Quellenangaben
Band: 98,
Artikelnummer: 104079
Verlag
Elsevier
Verlagsort
Radarweg 29, 1043 Nx Amsterdam, Netherlands
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Förderungen
European Union (European Fund for regional development) via the Technologie-Beratungs-Institut GmbH (TBI, Technology Consulting Institute of the Ministry of Economic Affairs, Infrastructure, Tourism and Labor Mecklenburg-Western Pomerania)
Research in the loan program "Zwan-zig20-Partnerschaft fur Innovation"
German Federal Ministry of Education and Research
Research in the loan program "Zwan-zig20-Partnerschaft fur Innovation"
German Federal Ministry of Education and Research