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Schneider, M.R.* ; Zettler, S.* ; Rathkolb, B. ; Dahlhoff, M.*

TXNIP overexpression in mice enhances streptozotocin-induced diabetes severity.

Mol. Cell. Endocrinol. 565:111885 (2023)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Thioredoxin-interacting protein (TXNIP) is a key player in the endocrine pancreas; it induces beta cell apoptosis, such that TXNIP deficiency promotes beta cell survival. To study its function in more detail, we generated transgenic mice with ubiquitous overexpression of TXNIP. CBATXNIP/+ mice were investigated under basal conditions and after being challenged in diet-induced obesity (DIO) and streptozotocin-induced type 1 diabetes mellitus (T1DM) models. TXNIP overexpression caused no effect in the DIO model, contrasting to the already reported TXNIP-deficient mice. However, in the T1DM background, CBATXNIP/+ animals showed significantly enhanced blood glucose and increased glucose levels in a glucose tolerance test. Finally, the beta cell mass of CBATXNIP/+ transgenic animals in the T1DM model was significantly reduced compared to control littermates. Our study demonstrates that overexpression of TXNIP doesn't affect blood glucose parameters under basal conditions. However, overexpression of TXNIP in a T1DM model enhances the severity of the disease.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Apoptosis ; Blood Glucose ; Diabetes Mellitus ; Diet-induced Obesity ; Mouse Model ; Txnip; Thioredoxin-interacting Protein; Up-regulated Protein-1; Betacellulin Overexpression; Insulin-secretion; Oxidative Stress; Glucose; Cells; Growth; Progression; Expression
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 0303-7207
e-ISSN 1872-8057
Zeitschrift Molecular and Cellular Endocrinology
Quellenangaben Band: 565, Heft: , Seiten: , Artikelnummer: 111885 Supplement: ,
Verlag Elsevier
Verlagsort Shannon
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Experimental Genetics (IEG)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-500692-001
DOI 10.1016/j.mce.2023.111885
WOS ID 000943232500001
Scopus ID 85149999030
PubMed ID 36773839
Erfassungsdatum 2023-02-23
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