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Büttner, P.* ; Böttner, J.* ; Krohn, K.* ; Baber, R.* ; Platzbecker, U.* ; Cross, M.* ; Desch, S.* ; Thiele, H.* ; Steiner, S. ; Scheinert, D.* ; Metzeler, K.H.* ; Branzan, D.

Clonal hematopoiesis mutations are present in atherosclerotic lesions in peripheral artery disease.

Int. J. Mol. Sci. 24:3962 (2023)
DOI PMC
Creative Commons Lizenzvertrag
Open Access Gold möglich sobald Verlagsversion bei der ZB eingereicht worden ist.
Clonal hematopoiesis (CH)-associated mutations increase the risk of atherosclerotic cardiovascular diseases. However, it is unclear whether the mutations detected in circulating blood cells can also be detected in tissues associated with atherosclerosis, where they could affect physiology locally. To address this, the presence of CH mutations in peripheral blood, atherosclerotic lesions and associated tissues was assessed in a pilot study of 31 consecutive patients with peripheral vascular disease (PAD) who underwent open surgical procedures. Next-generation sequencing was used to screen the most commonly mutated loci (DNMT3A, TET2, ASXL1 and JAK2). Twenty CH mutations were detected in peripheral blood of 14 (45%) patients, 5 of whom had more than one mutation. TET2 (11 mutations, 55%) and DNMT3A (8 mutations, 40%) were the most frequently affected genes. Altogether, 88% of the mutations detectable in peripheral blood were also present in the atherosclerotic lesions. Twelve patients also had mutations in perivascular fat or subcutaneous tissue. The presence of CH mutations in PAD-associated tissues as well as in blood suggests that CH mutations may make a previously unknown contribution to PAD disease biology.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Dnmt3a ; Tet2 ; Atherosclerosis ; Clonal Hematopoiesis ; Peripheral Artery Disease; Cardiovascular-disease; Esc Guidelines; Adipose-tissue; Heart-failure; Risk; Collaboration; Inflammation; Mechanism
ISSN (print) / ISBN 1422-0067
e-ISSN 1661-6596
Zeitschrift International Journal of Molecular Sciences
Quellenangaben Band: 24, Heft: 4, Seiten: , Artikelnummer: 3962 Supplement: ,
Verlag MDPI
Verlagsort Basel
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
Förderungen German Research Foundation
Leipzig University