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Subramanian, P.* ; Chavakis, T.

The complex function of macrophages and their subpopulations in metabolic injury associated fatty liver disease.

J. Physiol.-London 601, 1159-1171 (2023)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Nonalcoholic fatty liver disease (NAFLD), recently re-named to metabolic dysfunction associated fatty liver disease (MAFLD) is a major health problem, as it affects ∼25% of the population globally and is a major cause of hepatic cirrhosis and thereby liver failure, as well as hepatocellular carcinoma (HCC). MALFD comprises a broad range of pathological conditions in the liver, including simple fat accumulation (steatosis) and the more progressive non-alcoholic steatohepatitis (NASH) that can lead to fibrosis development. Cells of innate immunity, and particularly macrophages, comprising the liver resident Kupffer cells and the recruited monocyte-derived macrophages play complex roles in NASH-related inflammation and disease progression to fibrosis. Here, we discuss the recent developments with regards to the function of liver macrophage subpopulations during MAFLD development and progression. Abstract figure legend: Liver macrophages in metabolic dysfunction associated fatty liver disease. Different liver macrophage subpopulations, including Kupffer cells (KC) and monocyte-derived macrophages (MoMf), play multiple roles in the pathogenesis and progression of metabolic dysfunction associated fatty liver disease (MAFLD). This article is protected by copyright. All rights reserved.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Nash ; Skeynafld ; Inflammation ; Macrophages; Hepatic Stellate Cells; Kupffer Cells; Nonalcoholic Steatohepatitis; Fibrosis; Inflammation; Receptor; Nash; Pathogenesis; Cholesterol; Steatosis
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 0022-3751
e-ISSN 1469-7793
Zeitschrift Journal of Physiology - London
Quellenangaben Band: 601, Heft: 7, Seiten: 1159-1171 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Noboken, UK
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Pancreatic Islet Research (IPI)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502600-008
Förderungen Deutsche Forschungsgemeinschaft
Sonderzuweisung zur Unterstuetzung profilbestimmender Struktureinheiten 2021' by the SMWK(Saxon State Ministry of Science, Culture and Tourism)
DEEP-HCC project of the LiSyM-cancer program of the BMBF (Federal Ministry of Education and Research)
DOI 10.1113/JP283820
WOS ID 000947855100001
Scopus ID 85150603032
PubMed ID 36825510
Erfassungsdatum 2023-03-01
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