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Subramanian, P.* ; Chavakis, T.

The complex function of macrophages and their subpopulations in metabolic injury associated fatty liver disease.

J. Physiol.-London 601, 1159-1171 (2023)
DOI PMC
Creative Commons Lizenzvertrag
Nonalcoholic fatty liver disease (NAFLD), recently re-named to metabolic dysfunction associated fatty liver disease (MAFLD) is a major health problem, as it affects ∼25% of the population globally and is a major cause of hepatic cirrhosis and thereby liver failure, as well as hepatocellular carcinoma (HCC). MALFD comprises a broad range of pathological conditions in the liver, including simple fat accumulation (steatosis) and the more progressive non-alcoholic steatohepatitis (NASH) that can lead to fibrosis development. Cells of innate immunity, and particularly macrophages, comprising the liver resident Kupffer cells and the recruited monocyte-derived macrophages play complex roles in NASH-related inflammation and disease progression to fibrosis. Here, we discuss the recent developments with regards to the function of liver macrophage subpopulations during MAFLD development and progression. Abstract figure legend: Liver macrophages in metabolic dysfunction associated fatty liver disease. Different liver macrophage subpopulations, including Kupffer cells (KC) and monocyte-derived macrophages (MoMf), play multiple roles in the pathogenesis and progression of metabolic dysfunction associated fatty liver disease (MAFLD). This article is protected by copyright. All rights reserved.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Nash ; Skeynafld ; Inflammation ; Macrophages; Hepatic Stellate Cells; Kupffer Cells; Nonalcoholic Steatohepatitis; Fibrosis; Inflammation; Receptor; Nash; Pathogenesis; Cholesterol; Steatosis
ISSN (print) / ISBN 0022-3751
e-ISSN 1469-7793
Zeitschrift Journal of Physiology - London
Quellenangaben Band: 601, Heft: 7, Seiten: 1159-1171 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Noboken, UK
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Pancreatic Beta Cell Research (IPI)
Förderungen Deutsche Forschungsgemeinschaft
Sonderzuweisung zur Unterstuetzung profilbestimmender Struktureinheiten 2021' by the SMWK(Saxon State Ministry of Science, Culture and Tourism)
DEEP-HCC project of the LiSyM-cancer program of the BMBF (Federal Ministry of Education and Research)