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Thorsen, S.U.* ; Liu, X.* ; Kataria, Y.* ; Mandrup-Poulsen, T.* ; Kaur, S.* ; Uusitalo, U.* ; Virtanen, S.M.* ; Norris, J.M.* ; Rewers, M.* ; Hagopian, W.* ; Yang, J.* ; She, J.X.* ; Akolkar, B.* ; Rich, S.* ; Aronsson, C.A.* ; Lernmark, * ; Ziegler, A.-G. ; Toppari, J.* ; Krischer, J.* ; Parikh, H.M.* ; Ellervik, C.* ; Svensson, J.*

Interaction between dietary iron intake and genetically determined iron overload: Risk of islet autoimmunity and progression to Type 1 diabetes in the TEDDY study.

Diabetes Care 46, 1014-1018 (2023)
Postprint DOI PMC
Open Access Green
OBJECTIVE: To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: In The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression to T1D. Exposures included energy-adjusted iron intake in the first 3 years of life and a genetic risk score (GRS) for increased circulating iron. RESULTS: We found a U-shaped association between iron intake and risk of GAD antibody as the first autoantibody. In children with GRS ≥2 iron risk alleles, high iron intake was associated with an increased risk of IA, with insulin as first autoantibody (adjusted hazard ratio 1.71 [95% CI 1.14; 2.58]) compared with moderate iron intake. CONCLUSIONS: Iron intake may alter the risk of IA in children with high-risk HLA haplogenotypes.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Environmental Determinants; Autoantibodies
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 0149-5992
e-ISSN 1935-5548
Zeitschrift Diabetes Care
Quellenangaben Band: 46, Heft: 5, Seiten: 1014-1018 Artikelnummer: , Supplement: ,
Verlag American Diabetes Association
Verlagsort Alexandria, Va.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research (IDF)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502100-001
Förderungen National Institute of Allergy and Infectious Diseases
Eunice Kennedy Shriver National Institute of Child Health and Human Development
National Institute of Environmental Health Sciences
Centers for Disease Control and Prevention
JDRF
National Institutes of Health/National Center
University of Colorado
Fabrikant Vilhelm Pedersen og Hustrus Mindelegat

National Institute of Diabetes and Digestive and Kidney Diseases
DOI 10.2337/dc22-1359
WOS ID 001017248100035
Scopus ID 85159499696
PubMed ID 36867433
Erfassungsdatum 2023-03-08
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