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Papadogianni, G.* ; Ravens, I.* ; Hassan, A.* ; Flatley, A. ; Feederle, R. ; Bernhardt, G.* ; Georgiev, H.*

Establishment and functional characterization of murine monoclonal antibodies recognizing neuritin.

Antibodies 12:9 (2023)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Neuritin represents a neurotrophic factor that is not only important in neuronal development and plasticity but also impacts endothelial angiogenesis, cell migration, tumor growth and the production of antibodies by B cells. We established monoclonal mouse anti-mouse neuritin antibodies by immunizing knock-out mice with two different neuritin-derived peptides. Because neuritin is well conserved between species, these new monoclonal antibodies recognize the neuritin of a wide variety of species, including human. Moreover, they not only recognize specifically surface-bound neuritin expressed by murine follicular regulatory T cells but also the block binding of recombinant neuritin to germinal center B cells. This suggests that these newly generated tools will be of great use in studying neuritin expression and function.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Elisa ; Blocking Antibody ; Flow Cytometry ; Monoclonal Antibody ; Neuritin; Cpg15; Growth
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 2073-4468
e-ISSN 2073-4468
Zeitschrift Antibodies
Quellenangaben Band: 12, Heft: 2, Seiten: , Artikelnummer: 9 Supplement: ,
Verlag MDPI
Verlagsort St Alban-anlage 66, Ch-4052 Basel, Switzerland
Begutachtungsstatus Peer reviewed
Institut(e) CF Monoclonal Antibodies (CF-MAB)
POF Topic(s) 30201 - Metabolic Health
PSP-Element(e) A-631900-001
DOI 10.3390/antib12020028
WOS ID 001013821900001
Scopus ID 85163747310
PubMed ID 37092449
Erfassungsdatum 2023-10-06
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