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Hoffmann, C.* ; Schwarz, P.E. ; Mantzoros, C.S.* ; Birkenfeld, A.L. ; Wolfrum, C.* ; Solimena, M. ; Bornstein, S.R. ; Perakakis, N.

Circulating levels of gastrointestinal hormones in prediabetes reversing to normoglycemia or progressing to diabetes in a year-A cross-sectional and prospective analysis.

Diabetes Res. Clin. Pract. 199:110636 (2023)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
AIMS: We aimed to compare the concentrations of GLP-1, glucagon and GIP (established regulators of glucose homeostasis) and glicentin (emerging new metabolic marker)during an OGTT in patients with normal glucose tolerance (NGT), prediabetes and diabetes at onset, and one-year before, when all had prediabetes. METHODS: GLP-1, glucagon, GIP and glicentin concentrations were measured and compared with markers of body composition, insulin sensitivity and β-cell function at a 5-timepoint OGTT in 125 subjects (30 diabetes, 65 prediabetes, 30 NGT) and in 106 of them one-year before, when all had prediabetes. RESULTS: At baseline, when all subjects were in prediabetic state, hormonal levels did not differ between groups. One year later, patients progressing to diabetes had lower postprandial increases of glicentin and GLP-1, lower postprandial decrease of glucagon, and higher levels of fasting GIP compared to patients regressing to NGT. Changes in glicentin and GLP-1 AUC within this year correlated negatively with changes in Glucose AUC of OGTT and with changes in markers of beta cell function. CONCLUSION: Incretins, glucagon and glicentin profiles in prediabetic state cannot predict future glycemic traits, but prediabetes progressing to diabetes is accompanied by deterioration of postprandial increases of GLP-1 and glicentin.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Incretins ; Proglucagon-derived Peptides ; Type 2 Diabetes Mellitus; Glucagon-like Peptide-1; Dependent Insulinotropic Polypeptide; Commercially Available Assays; Oral Glucose; Type-2; Glp-1; Specificity; Sensitivity; Secretion
ISSN (print) / ISBN 0168-8227
e-ISSN 1872-8227
Zeitschrift Diabetes Research and Clinical Practice
Quellenangaben Band: 199, Heft: , Seiten: , Artikelnummer: 110636 Supplement: ,
Verlag Elsevier
Verlagsort Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Pancreatic Beta Cell Research (IPI)
Institute of Diabetes Research and Metabolic Diseases (IDM)
Förderungen BundesministeriumfrBildung und Foschung (BMBF) - DeutschesZen-trumfrDiabetesforschung
Deutsche Foschungsgemeinschaft (DFG)