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Zani, F.* ; Blagih, J.* ; Gruber, T. ; Buck, M.D.* ; Jones, N.* ; Hennequart, M.* ; Newell, C.L.* ; Pilley, S.E.* ; Soro-Barrio, P.* ; Kelly, G.* ; Legrave, N.M.* ; Cheung, E.C.* ; Gilmore, I.S.* ; Gould, A.P.* ; García-Cáceres, C. ; Vousden, K.H.*

The dietary sweetener sucralose is a negative modulator of T cell-mediated responses.

Nature 615, 705-711 (2023)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Artificial sweeteners are used as calorie-free sugar substitutes in many food products and their consumption has increased substantially over the past years1. Although generally regarded as safe, some concerns have been raised about the long-term safety of the consumption of certain sweeteners2-5. In this study, we show that the intake of high doses of sucralose in mice results in immunomodulatory effects by limiting T cell proliferation and T cell differentiation. Mechanistically, sucralose affects the membrane order of T cells, accompanied by a reduced efficiency of T cell receptor signalling and intracellular calcium mobilization. Mice given sucralose show decreased CD8+ T cell antigen-specific responses in subcutaneous cancer models and bacterial infection models, and reduced T cell function in models of T cell-mediated autoimmunity. Overall, these findings suggest that a high intake of sucralose can dampen T cell-mediated responses, an effect that could be used in therapy to mitigate T cell-dependent autoimmune disorders.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Taste Receptors; Activation; Association; Resolution; T1r3
ISSN (print) / ISBN 0028-0836
e-ISSN 1476-4687
Zeitschrift Nature
Quellenangaben Band: 615, Heft: 7953, Seiten: 705-711 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
Förderungen Francis Crick Institute from Cancer Research UK
UK Medical Research Council
Wellcome Trust
Cancer Research UK
EMBO Long-Term Fellowship
Marie Sklodowska-Curie Individual Fellowship
Kuok Family Fellowship
MRC New Investigator Research Grant
European Research Council ERC (STG grant AstroNeuroCrosstalk)
German Research Foundation DFG under Germany's Excellence Strategy
DFG under Helmholtz Excellence Network
Deutsche Forschungsgemeinschaft
Helmholtz Association-Initiative and Networking Fund
European Research Council (ERC)
Marie Curie Actions (MSCA)