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Massier, L.* ; Jalkanen, J.* ; Elmastas, M.* ; Zhong, J.* ; Wang, T.* ; Nono Nankam, P.A. ; Frendo-Cumbo, S.* ; Bäckdahl, J.* ; Subramanian, N.* ; Sekine, T.* ; Kerr, A.G.* ; Tseng, B.T.P.* ; Laurencikiene, J.* ; Buggert, M.* ; Lourda, M.* ; Kublickiene, K.* ; Bhalla, N.* ; Andersson, A.* ; Valsesia, A.* ; Astrup, A.* ; Blaak, E.E.* ; Ståhl, P.L.* ; Viguerie, N.* ; Langin, D.* ; Wolfrum, C.* ; Blüher, M. ; Rydén, M.* ; Mejhert, N.*

An integrated single cell and spatial transcriptomic map of human white adipose tissue.

Nat. Commun. 14:1438 (2023)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
To date, single-cell studies of human white adipose tissue (WAT) have been based on small cohort sizes and no cellular consensus nomenclature exists. Herein, we performed a comprehensive meta-analysis of publicly available and newly generated single-cell, single-nucleus, and spatial transcriptomic results from human subcutaneous, omental, and perivascular WAT. Our high-resolution map is built on data from ten studies and allowed us to robustly identify >60 subpopulations of adipocytes, fibroblast and adipogenic progenitors, vascular, and immune cells. Using these results, we deconvolved spatial and bulk transcriptomic data from nine additional cohorts to provide spatial and clinical dimensions to the map. This identified cell-cell interactions as well as relationships between specific cell subtypes and insulin resistance, dyslipidemia, adipocyte volume, and lipolysis upon long-term weight changes. Altogether, our meta-map provides a rich resource defining the cellular and microarchitectural landscape of human WAT and describes the associations between specific cell types and metabolic states.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Adipogenesis; Obesity; Health
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 14, Heft: 1, Seiten: , Artikelnummer: 1438 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
Förderungen Centre for Bioinformatics and Biostatistics at the Karolinska Institutet
Swedish Research Council
KI infrastructure
Centre for Innovative Medicine
Margareta af Uggla's foundation
Knut & Alice Wallenberg's foundation
ERC-SyG SPHERES
European Community
NovoNordisk Foundation (Tripartite Immuno-metabolism Consortium)
NovoNordisk Foundation (MSAM consortium)
National Genomics Infrastructure (NGI) in Genomics Production Stockholm
NovoNordisk Foundation
CIMED
Swedish Diabetes Foundation
Stockholm County Council
Strategic Research Program in Diabetes at Karolinska Institutet
European Foundation for the Study of Diabetes/Novo Nordisk Foundation Future Leaders Award
Karolinska Institute
Swedish Society for Medical Research (SSMF)
Swedish Childhood Cancer Fund

European Research Council (ERC)
NovoNordisk Foundation (MeRIAD consortium)