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Quagliarini, F. ; Makris, K. ; Friano, M.E. ; Uhlenhaut, N.H.

EJE Prize 2023: Genes on steroids-genomic control of hepatic metabolism by the glucocorticoid receptor.

Eur. J. Endocrinol. 188, R111-R130 (2023)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Glucocorticoids are essential hormones produced by the adrenal cortex with prominent circadian rhythmicity and in times of stress. Glucocorticoids maintain liver homeostasis through coordinated activities that control the major pathways of energy metabolism. Glucocorticoids activate the glucocorticoid receptor (GR), a nuclear hormone receptor that regulates the transcription of hundreds of genes in response to ligand. This review aims to provide a comprehensive overview of glucocorticoid receptor signaling impact on glucose, amino acid, and lipid metabolism in the liver. We integrate fundamental and current findings elucidating key GR-regulated pathways from a physiologic, biochemical, and molecular point-of-view. Here, we focus on the transcriptional regulation of well-characterized hepatic GR target genes, and on those GR co-factors that coordinate nutritional and hormonal signals.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Glucocorticoid Receptor ; Hormones ; Liver Metabolism ; Transcription; Phosphoenolpyruvate Carboxykinase Gene; Low-density-lipoprotein; Urea-cycle Enzymes; Alpha-ketoglutarate Transaminase; Tyrosine Aminotransferase Gene; Messenger-rna Levels; Very-low-density; Rev-erb-alpha; Tryptophan Oxygenase Gene; Activated Protein-kinase
ISSN (print) / ISBN 0804-4643
e-ISSN 1479-683X
Zeitschrift European Journal of Endocrinology
Quellenangaben Band: 188, Heft: 5, Seiten: R111-R130 Artikelnummer: , Supplement: ,
Verlag BioScientifica
Verlagsort Great Clarendon St, Oxford Ox2 6dp, England
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Endocrinology (IDE)