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Myeloperoxidase, but not oxidized LDL, is associated with leisure-time physical activity: Results from the MONICA/KORA Augsburg Studies 1984-1995.
Atherosclerosis 219, 774-777 (2011)
OBJECTIVE: Oxidative stress-induced cell damage contributes to several chronic conditions such as cardiovascular disease, but only very few population-based studies have examined the influence of regular physical activity (PA) on oxidative stress. METHODS: 1820 men and women aged 35-74 years were randomly drawn from three population-based MONICA/KORA Augsburg Studies conducted between 1984 and 1995. Geometric means of the oxidative stress markers myeloperoxidase (MPO) and oxidized LDL (ox-LDL) were calculated and multiple linear regression was performed to assess their associations with three self-reported PA domains, namely work, leisure-time or walking. RESULTS: Mean MPO concentrations were lower for participants engaged in high leisure-time PA (124.2μg/ml; 95%-CI, 116.8-132.0) compared to the inactive reference group (133.5μg/ml; 95%-CI, 127.6-139.6) (P(trend) across PA levels: 0.007). No significant association between ox-LDL and PA domains was observed (P(trend) between 0.162 and 0.803). CONCLUSION: These data indicate that regular leisure-time PA may reduce MPO concentrations.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
4.086
1.361
4
5
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Oxidative stress; MPO; ox-LDL; Domains of physical activity; Atherosclerosis; Population-based study
Sprache
englisch
Veröffentlichungsjahr
2011
HGF-Berichtsjahr
2011
ISSN (print) / ISBN
0021-9150
e-ISSN
1879-1484
Zeitschrift
Atherosclerosis
Quellenangaben
Band: 219,
Heft: 2,
Seiten: 774-777
Verlag
Elsevier
Verlagsort
Amsterdam
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Epidemiology (EPI)
POF Topic(s)
30202 - Environmental Health
30503 - Chronic Diseases of the Lung and Allergies
30503 - Chronic Diseases of the Lung and Allergies
Forschungsfeld(er)
Genetics and Epidemiology
PSP-Element(e)
G-504000-003
G-503900-001
G-504090-001
G-503900-001
G-504090-001
PubMed ID
21880315
Scopus ID
82955247648
Erfassungsdatum
2011-12-12