Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Taurine deficiency as a driver of aging.
Science 380:eabn9257 (2023)
Aging is associated with changes in circulating levels of various molecules, some of which remain undefined. We find that concentrations of circulating taurine decline with aging in mice, monkeys, and humans. A reversal of this decline through taurine supplementation increased the health span (the period of healthy living) and life span in mice and health span in monkeys. Mechanistically, taurine reduced cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, and attenuated inflammaging. In humans, lower taurine concentrations correlated with several age-related diseases and taurine concentrations increased after acute endurance exercise. Thus, taurine deficiency may be a driver of aging because its reversal increases health span in worms, rodents, and primates and life span in worms and rodents. Clinical trials in humans seem warranted to test whether taurine deficiency might drive aging in humans.
Altmetric
Weitere Metriken?
Zusatzinfos bearbeiten
[➜Einloggen]
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Amino-acid-concentrations; Stem-cells; Plasma; Pathways; Identification; Reproduction; Transporter; Metabolism; Regulators; Expression
ISSN (print) / ISBN
0036-8075
e-ISSN
1095-9203
Zeitschrift
Science
Quellenangaben
Band: 380,
Heft: 6649,
Artikelnummer: eabn9257
Verlag
American Association for the Advancement of Science (AAAS)
Verlagsort
1200 New York Ave, Nw, Washington, Dc 20005 Usa
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Computational Biology (ICB)
Förderungen
Institut National Du Cancer (INCa)
Deutsche Forschungsgemeinschaft (DFG)
Wellcome
National Institutes of Health (NIH)
Nathan Shock Center of Excellence in the Basic Biology of Aging Project
Department of Biotechnology (DBT)
Science and Engineering Research Board (SERB)
Academy of Finland Center of Excellence in Complex Disease Genetics
Sigrid Juselius Foundation
Larry L. Hillblom Foundation Fellowship
Victorian Cancer Agency (VCA) Fellowship
DBT Ramalingaswamy Fellowship
Longevity Impetus Grant
Deutsche Forschungsgemeinschaft (DFG)
Wellcome
National Institutes of Health (NIH)
Nathan Shock Center of Excellence in the Basic Biology of Aging Project
Department of Biotechnology (DBT)
Science and Engineering Research Board (SERB)
Academy of Finland Center of Excellence in Complex Disease Genetics
Sigrid Juselius Foundation
Larry L. Hillblom Foundation Fellowship
Victorian Cancer Agency (VCA) Fellowship
DBT Ramalingaswamy Fellowship
Longevity Impetus Grant