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Kapellos, T. ; Baßler, K.* ; Fujii, W.* ; Nalkurthi, C.* ; Schaar, A. ; Bonaguro, L.* ; Pecht, T.* ; Galvao, I.* ; Agrawal, S.* ; Saglam, A.* ; Dudkin, E.* ; Frishberg, A. ; De Domenico, E.* ; Horne, A.* ; Donovan, C.* ; Kim, R.Y.* ; Gallego-Ortega, D.* ; Gillett, T.E.* ; Ansari, M. ; Schulte-Schrepping, J.* ; Offermann, N.* ; Antignano, I.* ; Sivri, B.* ; Lu, W.* ; Eapen, M.S.* ; van Uelft, M.* ; Osei-Sarpong, C.* ; van den Berge, M.* ; Donker, H.C.* ; Groen, H.J.M.* ; Sohal, S.S.* ; Klein, J.* ; Schreiber, T.* ; Feißt, A.* ; Yildirim, A.Ö. ; Schiller, H. ; Nawijn, M.C.* ; Becker, M.* ; Händler, K.* ; Beyer, M.* ; Capasso, M.* ; Ulas, T.* ; Hasenauer, J. ; Pizarro, C.* ; Theis, F.J. ; Hansbro, P.M.* ; Skowasch, D.* ; Schultze, J.

Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease.

Cell Rep. 42:112525 (2023)
DOI PMC
Creative Commons Lizenzvertrag
Open Access Gold möglich sobald Verlagsversion bei der ZB eingereicht worden ist.
Systemic inflammation is established as part of late-stage severe lung disease, but molecular, functional, and phenotypic changes in peripheral immune cells in early disease stages remain ill defined. Chronic obstructive pulmonary disease (COPD) is a major respiratory disease characterized by small-airway inflammation, emphysema, and severe breathing difficulties. Using single-cell analyses we demonstrate that blood neutrophils are already increased in early-stage COPD, and changes in molecular and functional neutrophil states correlate with lung function decline. Assessing neutrophils and their bone marrow precursors in a murine cigarette smoke exposure model identified similar molecular changes in blood neutrophils and precursor populations that also occur in the blood and lung. Our study shows that systemic molecular alterations in neutrophils and their precursors are part of early-stage COPD, a finding to be further explored for potential therapeutic targets and biomarkers for early diagnosis and patient stratification.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Cp: Immunology ; Blood ; Bone Marrow ; Chronic Obstructive Pulmonary Disease ; Granulopoiesis ; Neutrophil ; Single-cell Transcriptomics; R Package; Copd; Homeostasis; Population; Expression
ISSN (print) / ISBN 2211-1247
e-ISSN 2211-1247
Zeitschrift Cell Reports
Quellenangaben Band: 42, Heft: 6, Seiten: , Artikelnummer: 112525 Supplement: ,
Verlag Cell Press
Verlagsort 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Lung Health and Immunity (LHI)
Institute of Computational Biology (ICB)
Institute of Lung Biology (LHI)
Förderungen UTS
National Health and Medical Research Council (NHMRC) of Australia
Helmholtz Zukunftsthema Immunology and Inflammation
Clifford Craig Foundation Launceston General Hospital
Joint Programming Initiative, A Healthy Diet for a Healthy Life (JPI HDHL)
Helmholtz
Germany's Excellence Strategy
German Research Foundation)
Deutsche Forschungsgemeinschaft (DFG
EU
EU Horizon 2020 project SYSCID
BMBF
Alexander von Humboldt Foundation