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Kabbani, N.* ; Blüher, M. ; Stepan, H.* ; Stumvoll, M.* ; Ebert, T.* ; Tönjes, A.* ; Schrey-Petersen, S.*

Adipokines in pregnancy: A systematic review of clinical data.

Biomedicines 11:25 (2023)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Adipokines are signaling proteins involved in metabolic, endocrinological, vascular and immunogenic processes. Associations of various adipokines with not only insulin resistance but also with increased insulin sensitivity, increased systolic blood pressure, and atherosclerosis highlight the significance of adipokines in several components of metabolic syndrome and metabolic diseases in general. As pregnancy presents a unique metabolic state, the role of adipokines in pregnancy, and even in various pregnancy complications, appears to be key to elucidating these metabolic processes. Many studies in recent years have attempted to clarify the role of adipokines in pregnancy and gestational pathologies. In this review, we aim to investigate the changes in maternal adipokine levels in physiological gestation, as well as the association of adipokines with pregnancy pathologies, such as gestational diabetes mellitus (GDM) and preeclampsia (PE). Furthermore, we will analyze the association of adipokines in both maternal serum and cord blood with parameters of intrauterine growth and various pregnancy outcomes.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Adipokines ; Gestational Diabetes ; Intrauterine Growth ; Preeclampsia ; Pregnancy; Gestational Diabetes-mellitus; Retinol-binding-protein; Maternal Serum Resistin; Adipose-tissue; 1st Trimester; Chemerin Level; Birth-weight; Visfatin Concentrations; Insulin-resistance; Omentin-1 Levels
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 2227-9059
e-ISSN 2227-9059
Zeitschrift Biomedicines
Quellenangaben Band: 11, Heft: 5, Seiten: , Artikelnummer: 25 Supplement: ,
Verlag MDPI
Verlagsort Basel, Switzerland
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-506501-001
Förderungen EFSD Mentorship Programme - AstraZeneca
Swedish Kidney Foundation (Njurfonden)
Deutsche Diabetes Gesellschaft (DDG)
Stiftelsen Stig och Gunborg Westman
Karolinska Institutet Research Foundation
Karolinska Institutet, Stockholm, Sweden
Novo Nordisk postdoctoral fellowship
medical faculty of the University of Leipzig
German Diabetes Association (DDG)
Deutsches Zentrum fur Diabetesforschung (DZD)
Deutsche Forschungsgemeinschaft (DFG, German Research foundation)
DOI 10.3390/biomedicines11051419
WOS ID 001011296600001
Scopus ID 85160725598
PubMed ID 37239090
Erfassungsdatum 2023-10-06
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