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Keshawarz, A.* ; Joehanes, R.* ; Ma, J.* ; Lee, G.Y.* ; Costeira, R.* ; Tsai, P.C.* ; Masachs, O.M.* ; Bell, J.T.* ; Wilson, R. ; Thorand, B. ; Winkelmann, J. ; Peters, A. ; Linseisen, J.* ; Waldenberger, M. ; Lehtimäki, T.* ; Mishra, P.P.* ; Kähönen, M.* ; Raitakari, O.* ; Helminen, M.* ; Wang, C.A.* ; Melton, P.E.* ; Huang, R.C.* ; Pennell, C.E.* ; O'Sullivan, T.A.* ; Ochoa-Rosales, C.* ; Voortman, T.* ; van Meurs, J.B.J.* ; Young, K.L.* ; Graff, M.* ; Wang, Y.* ; Kiel, D.P.* ; Smith, C.E.* ; Jacques, P.F.* ; Levy, D.*

Dietary and supplemental intake of vitamins C and E is associated with altered DNA methylation in an epigenome-wide association study meta-analysis.

Epigenetics 18:2211361 (2023)
Verlagsversion DOI PMC
Creative Commons Lizenzvertrag
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
BACKGROUND: Dietary intake of antioxidants such as vitamins C and E protect against oxidative stress, and may also be associated with altered DNA methylation patterns. METHODS: We meta-analysed epigenome-wide association study (EWAS) results from 11,866 participants across eight population-based cohorts to evaluate the association between self-reported dietary and supplemental intake of vitamins C and E with DNA methylation. EWAS were adjusted for age, sex, BMI, caloric intake, blood cell type proportion, smoking status, alcohol consumption, and technical covariates. Significant results of the meta-analysis were subsequently evaluated in gene set enrichment analysis (GSEA) and expression quantitative trait methylation (eQTM) analysis. RESULTS: In meta-analysis, methylation at 4,656 CpG sites was significantly associated with vitamin C intake at FDR ≤ 0.05. The most significant CpG sites associated with vitamin C (at FDR ≤ 0.01) were enriched for pathways associated with systems development and cell signalling in GSEA, and were associated with downstream expression of genes enriched in the immune response in eQTM analysis. Furthermore, methylation at 160 CpG sites was significantly associated with vitamin E intake at FDR ≤ 0.05, but GSEA and eQTM analysis of the top most significant CpG sites associated with vitamin E did not identify significant enrichment of any biological pathways investigated. CONCLUSIONS: We identified significant associations of many CpG sites with vitamin C and E intake, and our results suggest that vitamin C intake may be associated with systems development and the immune response.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Epigenetics ; Vitamin C ; Vitamin E ; Diet ; Epidemiology; Food Frequency Questionnaire; Oxidative Stress; Immune-response; Blood; Risk; Reproducibility; Inflammation; Reliability; Lipoprotein; Mechanisms
ISSN (print) / ISBN 1559-2294
e-ISSN 1559-2308
Zeitschrift Epigenetics
Quellenangaben Band: 18, Heft: 1, Seiten: , Artikelnummer: 2211361 Supplement: ,
Verlag Landes Bioscience
Verlagsort Austin, Tex.
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology II (EPI2)
Institute of Neurogenomics (ING)
Förderungen Juho Vainio Foundation
Paavo Nurmi Foundation
Finnish Foundation for Cardiovascular Research
Finnish Cultural Foundation
Sigrid Juselius Foundation
Tampere Tuberculosis Foundation
Emil Aaltonen Foundation
Yrjo Jahnsson Foundation
National Institutes of Health
Diabetes Research Foundation of Finnish Diabetes Association
European Union's Horizon 2020 research and innovation programme
European Research Council (ERC) advanced grants
Tampere University Hospital Supporting Foundation
Finnish Society of Clinical Chemistry
National Health and Medical Research Council of Australia
Canadian Institutes of Health Research
NHMRC
University of Western Australia (UWA)
Signe and Ane Gyllenberg Foundation
Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
Helmholtz Zentrum Muenchen -German Research Center for Environmental Health
German Federal Ministry of Education and Research (BMBF)
State of Bavaria
Munich Center of Health Sciences (MC- Health), Ludwig-Maximilians-Universitat, as part of LMUinnovativ
German Federal Ministry of Education and Research (BMBF) within the framework of the EU Joint Programming Initiative 'A Healthy Diet for a Healthy Life' (DIMENSION)
UK Biotechnology and Biological Sciences Research Council
JPI HDHL DIMENSION project
Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals
Medical Research Council
Versus Arthritis
European Union Horizon 2020
Chronic Disease Research Foundation (CDRF)
Zoe Ltd
National Institute for Health Research (NIHR) Clinical Research Network (CRN) and Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust
King's College London
Academy of Finland
Social Insurance Institution of Finland
Wellcome Trust
Ministry of Health, Welfare and Sports
European Commission (DG XII)
Municipality of Rotterdam
National Heart, Lung, and Blood Institute
National Human Genome Research Institute
National Institutes of Health and NIH Roadmap for Medical Research
Curtin University
National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH) and NIH Roadmap for Medical Research
NHLBI
Women and Infants Research Foundation
Telethon Kids Institute, Edith Cowan University
Murdoch University
University of Notre Dame Australia
The Raine Medical Research Foundation
University of Western Australia
Telethon Kids Institute
Women and Infants Research Foundation, Edith Cowan University
Raine Medical Research Foundation
Ministry of Education, Culture and Science
Australian Government
Government of Western Australia
National Health and Medical Research Council (NHMRC)
Erasmus MC University Medical Center
Erasmus University Rotterdam
Netherlands Organisation for Scientific Research (NWO)
Netherlands Organisation for Health Research and Development (ZonMw)
Research Institute for Diseases in the Elderly (RIDE)
The Netherlands Genomics Initiative (NGI)