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Kalgudde Gopal, S. ; Dai, R. ; Stefanska, A.M. ; Ansari, M. ; Zhao, J. ; Ramesh, P. ; Bagnoli, J.W.* ; Correa-Gallegos, D. ; Lin, Y. ; Christ, S. ; Angelidis, I. ; Lupperger, V. ; Marr, C. ; Davies, L.C.* ; Enard, W.* ; Machens, H.G.* ; Schiller, H. ; Jiang, D. ; Rinkevich, Y.

Wound infiltrating adipocytes are not myofibroblasts.

Nat. Commun. 14:3020 (2023)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The origins of wound myofibroblasts and scar tissue remains unclear, but it is assumed to involve conversion of adipocytes into myofibroblasts. Here, we directly explore the potential plasticity of adipocytes and fibroblasts after skin injury. Using genetic lineage tracing and live imaging in explants and in wounded animals, we observe that injury induces a transient migratory state in adipocytes with vastly distinct cell migration patterns and behaviours from fibroblasts. Furthermore, migratory adipocytes, do not contribute to scar formation and remain non-fibrogenic in vitro, in vivo and upon transplantation into wounds in animals. Using single-cell and bulk transcriptomics we confirm that wound adipocytes do not convert into fibrogenic myofibroblasts. In summary, the injury-induced migratory adipocytes remain lineage-restricted and do not converge or reprogram into a fibrosing phenotype. These findings broadly impact basic and translational strategies in the regenerative medicine field, including clinical interventions for wound repair, diabetes, and fibrotic pathologies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Cells; Fibroblasts; Fibrosis; Regeneration; Transition; Mechanisms; Expression; Repair; Tissue
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 14, Heft: 1, Seiten: , Artikelnummer: 3020 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Regenerative Biology and Medicine (IRBM)
Lung Health and Immunity (LHI)
Institute of AI for Health (AIH)
Förderungen European Union
Helmholtz Association
German Center for Lung Research (DZL)
European Research Council
Else-Kroener-Fresenius-Stiftung
Fritz-Thyssen-Stiftung
German Research Foundation
Human Frontier Science Program Career Development Award