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Eser, T.M.* ; Baranov, O.* ; Huth, M. ; Ahmed, M.I.M.* ; Deák, F.* ; Held, K.* ; Lin, L.* ; Pekayvaz, K.* ; Leunig, A.* ; Nicolai, L.* ; Pollakis, G.* ; Buggert, M.* ; Price, D.A.* ; Rubio-Acero, R.* ; Reich, J.* ; Falk, P.* ; Markgraf, A.* ; Puchinger, K.* ; Castelletti, N.* ; Olbrich, L.* ; Vanshylla, K.* ; Klein, F.* ; Wieser, A.* ; Hasenauer, J. ; Kroidl, I.* ; Hoelscher, M.* ; Geldmacher, C.*

Nucleocapsid-specific T cell responses associate with control of SARS-CoV-2 in the upper airways before seroconversion.

Nat. Commun. 14:2952 (2023)
Postprint DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Despite intensive research since the emergence of SARS-CoV-2, it has remained unclear precisely which components of the early immune response protect against the development of severe COVID-19. Here, we perform a comprehensive immunogenetic and virologic analysis of nasopharyngeal and peripheral blood samples obtained during the acute phase of infection with SARS-CoV-2. We find that soluble and transcriptional markers of systemic inflammation peak during the first week after symptom onset and correlate directly with upper airways viral loads (UA-VLs), whereas the contemporaneous frequencies of circulating viral nucleocapsid (NC)-specific CD4+ and CD8+ T cells correlate inversely with various inflammatory markers and UA-VLs. In addition, we show that high frequencies of activated CD4+ and CD8+ T cells are present in acutely infected nasopharyngeal tissue, many of which express genes encoding various effector molecules, such as cytotoxic proteins and IFN-γ. The presence of IFNG mRNA-expressing CD4+ and CD8+ T cells in the infected epithelium is further linked with common patterns of gene expression among virus-susceptible target cells and better local control of SARS-CoV-2. Collectively, these results identify an immune correlate of protection against SARS-CoV-2, which could inform the development of more effective vaccines to combat the acute and chronic illnesses attributable to COVID-19.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Virus; Infection; Proteins; Immunity; Hiv
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 14, Heft: 1, Seiten: , Artikelnummer: 2952 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Computational Biology (ICB)
Förderungen National Institutes of Health Research (NIHR)

National Institute for Health Research
Ministry for Education and Research
Deutsche Forschungsgemeinschaft
Bavarian State Ministry of Science and the Arts