Startseite
English
Erweiterte Suche
Durchblättern nach ...
Publikationen im Überblick
Ansprechpartner
Hilfe
Verlagsversion
DOI
PMC
 |
Open Access Gold |
|
möglich sobald bei der ZB eingereicht worden ist.
The impact of the cardiovascular component and somatic mutations on ageing.
Aging Cell 22:e13957 (2023)
Mechanistic insight into ageing may empower prolonging the lifespan of humans; however, a complete understanding of this process is still lacking despite a plethora of ageing theories. In order to address this, we investigated the association of lifespan with eight phenotypic traits, that is, litter size, body mass, female and male sexual maturity, somatic mutation, heart, respiratory, and metabolic rate. In support of the somatic mutation theory, we analysed 15 mammalian species and their whole-genome sequencing deriving somatic mutation rate, which displayed the strongest negative correlation with lifespan. All remaining phenotypic traits showed almost equivalent strong associations across this mammalian cohort, however, resting heart rate explained additional variance in lifespan. Integrating somatic mutation and resting heart rate boosted the prediction of lifespan, thus highlighting that resting heart rate may either directly influence lifespan, or represents an epiphenomenon for additional lower-level mechanisms, for example, metabolic rate, that are associated with lifespan.
Altmetric
Weitere Metriken?
Zusatzinfos bearbeiten
[➜Einloggen]
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Aging ; Animals ; Biology ; Biostatistics ; Female ; Humans ; Litter Size ; Longevity ; Male ; Mammals ; Mutation ; Phenotype; Heart-rate-variability; Metabolic-rate; Life-span; Phylogenetic Signal; Body-size; Atherosclerosis; Determinants; Mechanisms; Rates; Time
ISSN (print) / ISBN
1474-9718
e-ISSN
1474-9726
Zeitschrift
Aging Cell
Quellenangaben
Band: 22,
Heft: 10,
Artikelnummer: e13957
Verlag
Wiley
Verlagsort
111 River St, Hoboken 07030-5774, Nj Usa
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Computational Biology (ICB)
Institute of Experimental Genetics (IEG)
Institute for Allergy Research (IAF)
Institute of Experimental Genetics (IEG)
Institute for Allergy Research (IAF)
Förderungen
European Research Council (ERC)
Helmholtz Association under the joint research school "Munich School for Data Science -MUDS"
European Union
Helmholtz Association under the joint research school "Munich School for Data Science -MUDS"
European Union