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Mooshage, C.M.* ; Tsilingiris, D.* ; Schimpfle, L. ; Kender, Z. ; Aziz-Safaie, T.* ; Hohmann, A.* ; Szendroedi, J.* ; Nawroth, P.* ; Sturm, V.* ; Heiland, S.* ; Bendszus, M.* ; Kopf, S.* ; Kurz, F.T.* ; Jende, J.M.E.*

Insulin resistance is associated with the capillary permeability of thigh muscles in patients with type 2 diabetes.

J. Clin. Endocrinol. Metab. 109, e137-e144 (2023)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
OBJECTIVE: Insulin-mediated microvascular permeability and blood flow of skeletal muscle appears to be altered in the condition of insulin resistance. Previous studies on this effect used invasive procedures in humans or animals. The aim of this study was to demonstrate the feasibility of a non-invasive assessment of human muscles' microcirculation via dynamic contrast-enhanced (DCE)-MRI of skeletal muscle in patients with type two diabetes (T2D). METHODS: 56 participants (46 with T2D, 10 healthy controls, HC) underwent DCE-MRI of the right thigh at 3 Tesla. The constant of the musculature's microvascular permeability (Ktrans), extravascular extracellular volume fraction (ve), and plasma volume fraction (vp) were calculated. RESULTS: In T2D patients, skeletal muscle Ktrans was lower (HC 0.0677 ± 0.002 min-1, T2D 0.0664 ± 0.002 min-1; p = 0.042) while the homeostasis model assessment (HOMA)-index was higher in patients with T2D compared to HC (HC 2.72 ± 2.2, T2D 6.11 ± 6.2; p = 0.011). In T2D, Ktrans correlated negatively with insulin (r = -0.39, p = 0.018) and HOMA-index (r = -0.38, p = 0.020). CONCLUSION: The results signify that skeletal muscle DCE MRI can be employed as a non-invasive technique for the assessment of muscles' microcirculation in T2D. Our findings suggest that microvascular permeability of skeletal muscle is lowered in patients with T2D and that a decrease in microvascular permeability is associated with insulin resistance. These results are of interest with regards to the impact of muscle perfusion on diabetic complications such as diabetic sarcopenia.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Diabetic Sarcopenia ; Dynamic Contrast Enhanced Mri ; Mr Myography ; Muscle Mri ; Muscle Perfusion ; Perfusion Mri; Human Skeletal-muscle; Microvascular Permeability; Surface-area; Blood-flow; Perfusion; Glucose; Macromolecules; Extravasation; Mellitus; Density
ISSN (print) / ISBN 0021-972X
e-ISSN 1945-7197
Zeitschrift Journal of Clinical Endocrinology & Metabolism, The
Quellenangaben Band: 109, Heft: 1, Seiten: e137-e144 Artikelnummer: , Supplement: ,
Verlag Endocrine Society
Verlagsort Bethesda, Md.
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Cancer (IDC)
Förderungen German Research Council (DFG)
Novo Nordisk
Codman
Guerbet
Bayer
Novartis
Siemens
Else Kroner-Fresenius-Stiftung (EKFS)