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Hadian, K. ; Stockwell, B.R.*

The therapeutic potential of targeting regulated non-apoptotic cell death.

Nat. Rev. Drug Discov. 22, 723-742 (2023)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Cell death is critical for the development and homeostasis of almost all multicellular organisms. Moreover, its dysregulation leads to diverse disease states. Historically, apoptosis was thought to be the major regulated cell death pathway, whereas necrosis was considered to be an unregulated form of cell death. However, research in recent decades has uncovered several forms of regulated necrosis that are implicated in degenerative diseases, inflammatory conditions and cancer. The growing insight into these regulated, non-apoptotic cell death pathways has opened new avenues for therapeutic targeting. Here, we describe the regulatory pathways of necroptosis, pyroptosis, parthanatos, ferroptosis, cuproptosis, lysozincrosis and disulfidptosis. We discuss small-molecule inhibitors of the pathways and prospects for future drug discovery. Together, the complex mechanisms governing these pathways offer strategies to develop therapeutics that control non-apoptotic cell death.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Mixed Lineage Kinase; Poly(adp-ribose) Par Polymer; Interacting Protein-1 Rip1; Glutathione-peroxidase 4; Gamma-inducing Factor; Highly Potent; Nlrp3 Inflammasome; Domain-like; Lipid-peroxidation; Cognitive Impairment
ISSN (print) / ISBN 1474-1776
Zeitschrift Nature Reviews - Drug Discovery
Quellenangaben Band: 22, Heft: 9, Seiten: 723-742 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Signaling and Translation (SAT)
Förderungen NINDS
NCI grant