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Metal-organic frameworks and their composites for chronic wound healing: From bench to bedside.
Adv. Mater. 36:e2302587 (2023)
Chronic wounds are characterized by delayed and dysregulated healing processes. As such, they have emerged as an increasingly significant threat. The associated morbidity and socioeconomic toll are clinically and financially challenging, necessitating novel approaches in the management of chronic wounds. Metal-organic frameworks (MOFs) are an innovative type of porous coordination polymers, with low toxicity and high eco-friendliness. Documented anti-bacterial effects and pro-angiogenic activity predestine these nanomaterials as promising systems for the treatment of chronic wounds. In this context, the therapeutic applicability and efficacy of MOFs remain to be elucidated. We, therefore, review structural-functional properties of MOFs and their composite materials and discuss how their multifunctionality and customizability could be leveraged as a clinical therapy for chronic wounds. This article is protected by copyright. All rights reserved.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Biomaterials ; Chronic Wounds ; Metal-organic Frameworks ; Multifunctionality ; Nanomedicine; Tissue-repair; Bacteria; Nanoparticles; Regeneration; Hydrogels; Release; Acid
ISSN (print) / ISBN
0935-9648
e-ISSN
1521-4095
Zeitschrift
Advanced materials
Quellenangaben
Band: 36,
Heft: 2,
Artikelnummer: e2302587
Verlag
Wiley
Verlagsort
Weinheim
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Regenerative Biology (IRBM)
Förderungen
European Union
German Research Foundation
China Postdoctoral Science Foundation
Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration
National Science Foundation of China
Y.X. and Q.F. contributed equally to this work. This work was supported by the National Science Foundation of China (No. 82002313, 82072444, 31900963, and 82202714), the Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration
German Research Foundation
China Postdoctoral Science Foundation
Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration
National Science Foundation of China
Y.X. and Q.F. contributed equally to this work. This work was supported by the National Science Foundation of China (No. 82002313, 82072444, 31900963, and 82202714), the Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration