Xiong, Y.* ; Feng, Q.* ; Lu, L.* ; Qiu, X.* ; Knoedler, S. ; Panayi, A.C.* ; Jiang, D. ; Rinkevich, Y. ; Lin, Z.* ; Mi, B.* ; Liu, G.* ; Zhao, Y.*
     
 
    
        
Metal-organic frameworks and their composites for chronic wound healing: From bench to bedside.
    
    
        
    
    
        
        Adv. Mater. 36:e2302587 (2023)
    
    
    
		
		
			
				Chronic wounds are characterized by delayed and dysregulated healing processes. As such, they have emerged as an increasingly significant threat. The associated morbidity and socioeconomic toll are clinically and financially challenging, necessitating novel approaches in the management of chronic wounds. Metal-organic frameworks (MOFs) are an innovative type of porous coordination polymers, with low toxicity and high eco-friendliness. Documented anti-bacterial effects and pro-angiogenic activity predestine these nanomaterials as promising systems for the treatment of chronic wounds. In this context, the therapeutic applicability and efficacy of MOFs remain to be elucidated. We, therefore, review structural-functional properties of MOFs and their composite materials and discuss how their multifunctionality and customizability could be leveraged as a clinical therapy for chronic wounds. This article is protected by copyright. All rights reserved.
			
			
				
			
		 
		
			
				
					
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        Publikationstyp
        Artikel: Journalartikel
    
 
    
        Dokumenttyp
        Review
    
 
    
        Typ der Hochschulschrift
        
    
 
    
        Herausgeber
        
    
    
        Schlagwörter
        Biomaterials ; Chronic Wounds ; Metal-organic Frameworks ; Multifunctionality ; Nanomedicine; Tissue-repair; Bacteria; Nanoparticles; Regeneration; Hydrogels; Release; Acid
    
 
    
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        Sprache
        englisch
    
 
    
        Veröffentlichungsjahr
        2023
    
 
    
        Prepublished im Jahr 
        0
    
 
    
        HGF-Berichtsjahr
        2023
    
 
    
    
        ISSN (print) / ISBN
        0935-9648
    
 
    
        e-ISSN
        1521-4095
    
 
    
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	    Band: 36,  
	    Heft: 2,  
	    Seiten: ,  
	    Artikelnummer: e2302587 
	    Supplement: ,  
	
    
 
  
        
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            Verlag
            Wiley
        
 
        
            Verlagsort
            Weinheim
        
 
	
        
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        Begutachtungsstatus
        Peer reviewed
    
 
    
        Institut(e)
        Institute of Regenerative Biology and Medicine (IRBM)
    
 
    
        POF Topic(s)
        30202 - Environmental Health
    
 
    
        Forschungsfeld(er)
        Lung Research
    
 
    
        PSP-Element(e)
        G-509400-001
    
 
    
        Förderungen
        European Union
German Research Foundation
China Postdoctoral Science Foundation
Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration
National Science Foundation of China
Y.X. and Q.F. contributed equally to this work. This work was supported by the National Science Foundation of China (No. 82002313, 82072444, 31900963, and 82202714), the Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration 
    
 
    
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        Erfassungsdatum
        2023-10-06