Startseite
English
Erweiterte Suche
Durchblättern nach ...
Publikationen im Überblick
Ansprechpartner
Hilfe
DOI
PMC
 |
|
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The state of brain activity modulates cerebrospinal fluid transport.
Prog. Neurobiol. 229:102512 (2023)
Earlier studies based on 2-photon imaging have shown that glymphatic cerebrospinal fluid (CSF) transport is regulated by the sleep-wake cycle. To examine this association, we used 3DISCO whole-body tissue clearing to map CSF tracer distribution in awake, sleeping and ketamine-xylazine anesthetized mice. The results of our analysis showed that CSF tracers entered the brain to a significantly larger extent in natural sleep or ketamine-xylazine anesthesia than in wakefulness. Furthermore, awake mice showed preferential transport of CSF tracers in the rostro-caudal direction towards the cervical and spinal cord lymphatic vessels, and hence to venous circulation and excretion by the kidneys. The study extends the current literature by showing that CSF dynamics on the whole-body scale is controlled by the state of brain activity.
Altmetric
Weitere Metriken?
Zusatzinfos bearbeiten
[➜Einloggen]
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Cerebrospinal Fluid ; Neurodegeneration ; Neuromodulators ; Perivascular Spaces ; Sleep ; Tissue Clearance; Meningeal Lymphatic Drainage; Extracellular-space; Glymphatic System; Sleep Quality; Pathology; Clearance; Disease; Organs; Mice
ISSN (print) / ISBN
0301-0082
e-ISSN
1873-5118
Zeitschrift
Progress in Neurobiology
Quellenangaben
Band: 229,
Artikelnummer: 102512
Verlag
Elsevier
Verlagsort
The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, England
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute for Tissue Engineering and Regenerative Medicine (ITERM)
Förderungen
Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
JPND Program
Simons Foundation
Human Frontier Science Program
US Army Research Office
National Institutes of Health
Novo Nordisk Foundation
Lundbeck Foundation
JPND Program
Simons Foundation
Human Frontier Science Program
US Army Research Office
National Institutes of Health
Novo Nordisk Foundation
Lundbeck Foundation