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Miyakoshi, L.M.* ; Stæger, F.F.* ; Li, Q.* ; Pan, C. ; Xie, L.* ; Kang, H.* ; Pavan, C.* ; Dang, J.* ; Sun, Q.* ; Ertürk, A. ; Nedergaard, M.*

The state of brain activity modulates cerebrospinal fluid transport.

Prog. Neurobiol. 229:102512 (2023)
DOI PMC
Earlier studies based on 2-photon imaging have shown that glymphatic cerebrospinal fluid (CSF) transport is regulated by the sleep-wake cycle. To examine this association, we used 3DISCO whole-body tissue clearing to map CSF tracer distribution in awake, sleeping and ketamine-xylazine anesthetized mice. The results of our analysis showed that CSF tracers entered the brain to a significantly larger extent in natural sleep or ketamine-xylazine anesthesia than in wakefulness. Furthermore, awake mice showed preferential transport of CSF tracers in the rostro-caudal direction towards the cervical and spinal cord lymphatic vessels, and hence to venous circulation and excretion by the kidneys. The study extends the current literature by showing that CSF dynamics on the whole-body scale is controlled by the state of brain activity.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Cerebrospinal Fluid ; Neurodegeneration ; Neuromodulators ; Perivascular Spaces ; Sleep ; Tissue Clearance; Meningeal Lymphatic Drainage; Extracellular-space; Glymphatic System; Sleep Quality; Pathology; Clearance; Disease; Organs; Mice
ISSN (print) / ISBN 0301-0082
e-ISSN 1873-5118
Zeitschrift Progress in Neurobiology
Quellenangaben Band: 229, Heft: , Seiten: , Artikelnummer: 102512 Supplement: ,
Verlag Elsevier
Verlagsort The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, England
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Tissue Engineering and Regenerative Medicine (ITERM)
Förderungen Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
JPND Program
Simons Foundation
Human Frontier Science Program
US Army Research Office
National Institutes of Health
Novo Nordisk Foundation
Lundbeck Foundation