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Wang, J.* ; Horlacher, M. ; Cheng, L.* ; Winther, O.*

RNA trafficking and subcellular localization-a review of mechanisms, experimental and predictive methodologies.

Brief. Bioinform. 24:14 (2023)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
RNA localization is essential for regulating spatial translation, where RNAs are trafficked to their target locations via various biological mechanisms. In this review, we discuss RNA localization in the context of molecular mechanisms, experimental techniques and machine learning-based prediction tools. Three main types of molecular mechanisms that control the localization of RNA to distinct cellular compartments are reviewed, including directed transport, protection from mRNA degradation, as well as diffusion and local entrapment. Advances in experimental methods, both image and sequence based, provide substantial data resources, which allow for the design of powerful machine learning models to predict RNA localizations. We review the publicly available predictive tools to serve as a guide for users and inspire developers to build more effective prediction models. Finally, we provide an overview of multimodal learning, which may provide a new avenue for the prediction of RNA localization.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Rna ; Localization ; Machine Learning ; Multimodality ; Subcellular; Bicoid Messenger-rna; Motor-neuron Smn; Binding Protein; Gene-expression; Spatial-organization; Local Translation; Global Analysis; Cell Polarity; Reveals; Transport
ISSN (print) / ISBN 1467-5463
e-ISSN 1477-4054
Zeitschrift Briefings in Bioinformatics
Quellenangaben Band: 24, Heft: 5, Seiten: , Artikelnummer: 14 Supplement: ,
Verlag Oxford University Press
Verlagsort Great Clarendon St, Oxford Ox2 6dp, England
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Computational Biology (ICB)
Förderungen Danish National Research Foundation
Novo Nordisk Foundation
China Scholarship Council (CSC)