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Hinney, A.* ; Scherag, A.* ; Jarick, I.* ; Albayrak, Ö.* ; Pütter, C.* ; Pechlivanis, S.* ; Dauvermann, M.R.* ; Beck, S.* ; Weber, H.* ; Scherag, S.* ; Nguyen, T.T.* ; Volckmar, A.L.* ; Knoll, N.* ; Faraone, S.V.* ; Neale, B.M.* ; Franke, B.* ; Cichon, S.* ; Hoffmann, P.* ; Nöthen, M.M.* ; Schreiber, S.* ; Jöckel, K.-H.* ; Wichmann, H.-E. ; Freitag, C.* ; Lempp, T.* ; Meyer, J.* ; Gilsbach, S.* ; Herpertz-Dahlmann, B.* ; Sinzig, J.* ; Lehmkuhl, G.* ; Renner, T.J.* ; Warnke, A.* ; Romanos, M.* ; Lesch, K.P.* ; Reif, A.* ; Schimmelmann, B.G.* ; Hebebrand, J.* ; Psychiatric GWAS Consortium ADHD Subgroup (*)

Genome-wide association study in German patients with attention deficit/hyperactivity disorder.

Am. J. Med. Genet. B 156B, 888-897 (2011)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The heritability of attention deficit hyperactivity disorder (ADHD) is approximately 0.8. Despite several larger scale attempts, genome-wide association studies (GWAS) have not led to the identification of significant results. We performed a GWAS based on 495 German young patients with ADHD (according to DSM-IV criteria; Human660W-Quadv1; Illumina, San Diego, CA) and on 1,300 population-based adult controls (HumanHap550v3; Illumina). Some genes neighboring the single nucleotide polymorphisms (SNPs) with the lowest P-values (best P-value: 8.38 × 10(-7)) have potential relevance for ADHD (e.g., glutamate receptor, metabotropic 5 gene, GRM5). After quality control, the 30 independent SNPs with the lowest P-values (P-values ≤ 7.57 × 10(-5) ) were chosen for confirmation. Genotyping of these SNPs in up to 320 independent German families comprising at least one child with ADHD revealed directionally consistent effect-size point estimates for 19 (10 not consistent) of the SNPs. In silico analyses of the 30 SNPs in the largest meta-analysis so far (2,064 trios, 896 cases, and 2,455 controls) revealed directionally consistent effect-size point estimates for 16 SNPs (11 not consistent). None of the combined analyses revealed a genome-wide significant result. SNPs in previously described autosomal candidate genes did not show significantly lower P-values compared to SNPs within random sets of genes of the same size. We did not find genome-wide significant results in a GWAS of German children with ADHD compared to controls. The second best SNP is located in an intron of GRM5, a gene located within a recently described region with an infrequent copy number variation in patients with ADHD.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter psychiatric; children; early onset; homogeneous
ISSN (print) / ISBN 1552-4841
e-ISSN 0148-7299
Zeitschrift American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Quellenangaben Band: 156B, Heft: 8, Seiten: 888-897 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Hoboken, NJ
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Molecular Epidemiology (AME)
Institute of Epidemiology (EPI)