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Nakatani, T. ; Torres-Padilla, M.E.

Regulation of mammalian totipotency: A molecular perspective from in vivo and in vitro studies.

Curr. Opin. Genet. Dev. 81:102083 (2023)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
In mammals, cells acquire totipotency at fertilization. Embryonic genome activation (EGA), which occurs at the 2-cell stage in the mouse and 4- to 8-cell stage in humans, occurs during the time window at which embryonic cells are totipotent and thus it is thought that EGA is mechanistically linked to the foundations of totipotency. The molecular mechanisms that lead to the establishment of totipotency and EGA had been elusive for a long time, however, recent advances have been achieved with the establishment of new cell lines with greater developmental potential and the application of novel low-input high-throughput techniques in embryos. These have unveiled several principles of totipotency related to its epigenetic makeup but also to characteristic features of totipotent cells. In this review, we summarize and discuss current views exploring some of the key drivers of totipotency from both in vitro cell culture models and embryogenesis in vivo.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Chromatin Assembly Factor-1; Zygotic Genome Activation; Embryonic-like Cells; Gene-expression; Stem-cells; Mouse; Dux; Transcription; Populations; Metabolism
ISSN (print) / ISBN 0959-437X
e-ISSN 1879-0380
Zeitschrift Current Opinion in Genetics & Development
Quellenangaben Band: 81, Heft: , Seiten: , Artikelnummer: 102083 Supplement: ,
Verlag Elsevier
Verlagsort 84 Theobalds Rd, London Wc1x 8rr, England
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epigenetics and Stem Cells (IES)
Förderungen German Research Foundation (DFG) through the CRC Chromatin Dynamics
National Institutes of Health (NIH)
Helmholtz Association