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Bacterial outer membrane vesicles as cationic dye carriers for optoacoustics-guided phototherapy of cancer.
Cancer Nanotechnol. 14:36 (2023)
Background: Cationic dyes are widely used as biomarkers for optical imaging. However, most of these are hydrophobic and cannot be employed in vivo without chemical conjugation or modification. Herein, we report for the first time the use of bacterial outer membrane vesicles (OMVs) as nanocarriers of cationic dyes for cancer theranostics. Results: We demonstrate that cationic dyes (IR780, Cy7, and Cy7.5) form stable complexes with negatively charged bacterial-OMVs, improving the dyes’ in vivo circulation and optoacoustic properties. Such OMV-Dye complexes are biodegradable and safe for in vivo applications. Importantly, this method of cationic dye loading is faster and easier than synthetic chemistry approaches, and the efficient tumor accumulation of OMV-Dyes enables sensitive tumor detection using optoacoustic technology. As a proof-of-concept, we generated OMV-IR780 for optoacoustics-guided in vivo tumor phototherapy in a mouse model. Conclusions: Our results demonstrate cationic dye-bound OMVs as promising novel nanoagents for tumor theranostics.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Bacterial Outer Membrane Vesicles ; Cationic Dyes ; Electrostatic Interaction ; Optoacoustics ; Phototherapy; Nanoparticles; Probes
ISSN (print) / ISBN
1868-6958
e-ISSN
1868-6966
Zeitschrift
Cancer Nanotechnology
Quellenangaben
Band: 14,
Heft: 1,
Artikelnummer: 36
Verlag
Springer
Verlagsort
Campus, 4 Crinan St, London N1 9xw, England
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed