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Hummel, S. ; Ziegler, A.-G.

Genetische Prädisposition und Umweltfaktoren in der Pathogenese des Typ-1-Diabetes.

Genetic predisposition and environmental factors in the pathogenesis of type 1 diabetes.

Internist. Prax. 66, 373-383 (2023)
Type 1 diabetes (T1D) is one of the most common chronic diseases in childhood caused by autoimmune-mediated destruction of the insulin-producing pancreatic islet ß-cells. Prospective birth cohort studies contributed to the identification of genetic and environmental factors involved in the pathogenesis of type 1 diabetes. The development and validation of a genetic risk score enabled risk prediction for later development of type 1 diabetes. Consistent findings from prospective studies point to the contribution of intrauterine maternal type 1 diabetes exposure, early childhood viral infections, early childhood growth/obesity, and gut microbiome/dysbiosis in the pathogenesis of type 1 diabetes. Launched in late 2017, the Global Platform for the Prevention of Autoimmune Diabetes (GPPAD) was designed to carry out newborn screening in the general population, identify infants at high genetic risk of developing type 1 diabetes, and offer them participation in trials to prevent disease initiation.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Environmental Factors– Prediction ; Genetics ; Islet Autoimmunity ; Type 1 Diabetes
ISSN (print) / ISBN 0020-9570
Zeitschrift Internistische Praxis
Quellenangaben Band: 66, Heft: 3, Seiten: 373-383 Artikelnummer: , Supplement: ,
Verlag Mediengruppe Oberfranken Fachverlag
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research (IDF)