PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Fadel, L. ; Dacic, M.* ; Fonda, V. ; Sokolsky, B.A.* ; Quagliarini, F. ; Rogatsky, I.* ; Uhlenhaut, N.H.

Modulating glucocorticoid receptor actions in physiology and pathology: Insights from coregulators.

Pharmacol. Ther. 251:108531 (2023)
Postprint DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Glucocorticoids (GCs) are a class of steroid hormones that regulate key physiological processes such as metabolism, immune function, and stress responses. The effects of GCs are mediated by the glucocorticoid receptor (GR), a ligand-dependent transcription factor that activates or represses the expression of hundreds to thousands of genes in a tissue- and physiological state-specific manner. The activity of GR is modulated by numerous coregulator proteins that interact with GR in response to different stimuli assembling into a multitude of DNA-protein complexes and facilitate the integration of these signals, helping GR to communicate with basal transcriptional machinery and chromatin. Here, we provide a brief overview of the physiological and molecular functions of GR, and discuss the roles of GR coregulators in the immune system, key metabolic tissues and the central nervous system. We also present an analysis of the GR interactome in different cells and tissues, which suggests tissue-specific utilization of GR coregulators, despite widespread functions shared by some of them.
Impact Factor
Scopus SNIP
Altmetric
13.500
2.796
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Coregulators ; Glucocorticoid Receptor ; Transcription; Corticotropin-releasing Hormone; Circadian Clock; Adipocyte Differentiation; Insulin Regulation; Lipid-metabolism; Gene; Expression; Chromatin; Transcription; Coactivator
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 0163-7258
e-ISSN 1879-016X
Zeitschrift Pharmacology & Therapeutics.
Quellenangaben Band: 251, Heft: , Seiten: , Artikelnummer: 108531 Supplement: ,
Verlag Elsevier
Verlagsort The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, England
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Endocrinology (IDE)
POF Topic(s) 30202 - Environmental Health
30201 - Metabolic Health
Forschungsfeld(er)
Helmholtz Diabetes Center
PSP-Element(e) G-501900-259
G-509500-001
Förderungen NIDDK NIH HHS
NIAID NIH HHS
DOI 10.1016/j.pharmthera.2023.108531
WOS ID 001097526300001
Scopus ID 85172780155
PubMed ID 37717739
Erfassungsdatum 2023-10-18
[➜Korrektur melden]