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Matta Pereira, L. ; Breves, C.* ; Fonte Boa, L.* ; Domingos, A.E.* ; Faria, C.C.* ; Souza, I.* ; Correia Lima-Junior, N.* ; Rocha, A.P.T.* ; Gregorio, B.M.* ; Carvalho, D.P.* ; Ferreira, A.C.F.* ; Nascimento, J.H.M.* ; Maciel, L.* ; Fortunato, R.S.*

Quercetin improves white adipose tissue redox homeostasis in ovariectomized rats.

J. Endocrinol. 259:e230166 (2023)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Estrogen deficiency is a well-known hallmark of menopause and is associated with oxidative stress and metabolic dysfunction. Quercetin (Q), a flavonoid found in fruits and vegetables, has demonstrated anti-inflammatory effects in experimental models of metabolic disorders. In this study, we aimed to investigate the effects of quercetin on retroperitoneal white adipose tissue (rWAT) redox homeostasis and systemic metabolic parameters in ovariectomized (OVX) rats. Female Wistar rats at 3 months old were divided into the following experimental groups: sham-operated treated with vehicle (DMSO 10% + PBS - 1 mL/kg); OVX (vehicle treated) and OVX-Q (25 mg/kg) - via oral gavage, daily for 5 weeks. Q did not prevent weight gain but improved glucose tolerance and blood cholesterol profile, and attenuated uterine atrophy in OVX rats. Furthermore, Q had a protective effect on rWAT, once the OVX-Q group presented lower oxidative stress levels, and reduced levels of the pro-inflammatory cytokine tumor necrosis factor alpha, compared to the OVX group. Q improved antioxidant enzyme activities such as superoxide dismutase and catalase and decreased reactive oxygen species production, in OVX-Q rats. It was followed by increased levels of total thiol content and lower lipid peroxidation. Moreover, Q reduced senescent-related genes p16INK4a and p19ARF expression which were higher in the OVX group. In conclusion, quercetin supplementation improved redox homeostasis and reduced senescence-related markers, and inflammation in rWAT, which was reflected in preserved systemic metabolic health parameters in OVX rats. These findings suggest that quercetin may have therapeutic potential for the management of metabolic disorders associated with menopause-induced estrogen deficiency.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Adipose Tissue ; Metabolic Dysfunction ; Ovariectomy ; Oxidative Stress; Proliferative Changes; Sexual-dimorphism; Estrogen; Expression; Uteri; Mice
ISSN (print) / ISBN 0022-0795
e-ISSN 1479-6805
Zeitschrift Journal of Endocrinology
Quellenangaben Band: 259, Heft: 2, Seiten: , Artikelnummer: e230166 Supplement: ,
Verlag Society for Endocrinology
Verlagsort Starling House, 1600 Bristol Parkway N, Bristol, England
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Cancer (IDC)
Förderungen Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ)
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)