PuSH - Publikationsserver des Helmholtz Zentrums München

Taylor, J.* ; Uhl, L.* ; Moll, I.* ; Hasan, S.S.* ; Wiedmann, L.* ; Morgenstern, J.* ; Giaimo, B.D.* ; Friedrich, T.* ; Alsina-Sanchis, E.* ; De Angelis Rigotti, F.* ; Mülfarth, R.* ; Kaltenbach, S.* ; Schenk, D.* ; Nickel, F.* ; Fleming, T.* ; Sprinzak, D.* ; Mogler, C.* ; Korff, T.* ; Billeter, A.T.* ; Müller-Stich, B.P.* ; Berriel Diaz, M. ; Borggrefe, T.* ; Herzig, S. ; Rohm, M. ; Rodriguez-Vita, J.* ; Fischer, A.*

Endothelial Notch1 signaling in white adipose tissue promotes cancer cachexia.

Nat. Cancer 4, 1544-1560 (2023)
Verlagsversion DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Cachexia is a major cause of morbidity and mortality in individuals with cancer and is characterized by weight loss due to adipose and muscle tissue wasting. Hallmarks of white adipose tissue (WAT) remodeling, which often precedes weight loss, are impaired lipid storage, inflammation and eventually fibrosis. Tissue wasting occurs in response to tumor-secreted factors. Considering that the continuous endothelium in WAT is the first line of contact with circulating factors, we postulated whether the endothelium itself may orchestrate tissue remodeling. Here, we show using human and mouse cancer models that during precachexia, tumors overactivate Notch1 signaling in distant WAT endothelium. Sustained endothelial Notch1 signaling induces a WAT wasting phenotype in male mice through excessive retinoic acid production. Pharmacological blockade of retinoic acid signaling was sufficient to inhibit WAT wasting in a mouse cancer cachexia model. This demonstrates that cancer manipulates the endothelium at distant sites to mediate WAT wasting by altering angiocrine signals.
Altmetric
Weitere Metriken?
[➜Einloggen]
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Retinoic Acid; Expression; Il-33; Thermogenesis; Angiogenesis; Inflammation; Inhibition; Blockade; Growth
ISSN (print) / ISBN 2662-1347
e-ISSN 2662-1347
Zeitschrift Nature Cancer
Quellenangaben Band: 4, Heft: 11, Seiten: 1544-1560 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort Heidelberger Platz 3, Berlin, 14197, Germany
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Cancer (IDC)
Förderungen Deutsche Forschungsgemeinschaft (German Research Foundation)