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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Emerging principles of primary cilia dynamics in controlling tissue organization and function.
EMBO J. 42, e113891 (2023)
Verlagsversion
DOI
PMC
Primary cilia project from the surface of most vertebrate cells and are key in sensing extracellular signals and locally transducing this information into a cellular response. Recent findings show that primary cilia are not merely static organelles with a distinct lipid and protein composition. Instead, the function of primary cilia relies on the dynamic composition of molecules within the cilium, the context-dependent sensing and processing of extracellular stimuli, and cycles of assembly and disassembly in a cell- and tissue-specific manner. Thereby, primary cilia dynamically integrate different cellular inputs and control cell fate and function during tissue development. Here, we review the recently emerging concept of primary cilia dynamics in tissue development, organization, remodeling, and function.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Cilia Dynamics ; Ciliary Signaling ; Cilium Disassembly ; Primary Cilia ; Tissue Organization; Protein-coupled Receptors; Bardet-biedl-syndrome; Retinal-pigment Epithelium; Left-right Asymmetry; Planar Cell Polarity; Ift-a Complex; Intraflagellar Transport; Extracellular Vesicles; Leftward Flow; Proteomic Analysis
ISSN (print) / ISBN
0261-4189
e-ISSN
1460-2075
Zeitschrift
EMBO Journal, The
Quellenangaben
Band: 42,
Heft: 21,
Seiten: e113891
Verlag
Wiley
Verlagsort
Heidelberg, Germany
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute for Pancreatic Beta Cell Research (IPI)
Förderungen
European Research Council