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Gopalakrishnan, J.* ; Feistel, K.* ; Friedrich, B.M.* ; Grapin-Botton, A. ; Jurisch-Yaksi, N.* ; Mass, E.* ; Mick, D.U.* ; Müller, R.U.* ; May-Simera, H.* ; Schermer, B.* ; Schmidts, M.* ; Walentek, P.* ; Wachten, D.*

Emerging principles of primary cilia dynamics in controlling tissue organization and function.

EMBO J. 42, e113891 (2023)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Primary cilia project from the surface of most vertebrate cells and are key in sensing extracellular signals and locally transducing this information into a cellular response. Recent findings show that primary cilia are not merely static organelles with a distinct lipid and protein composition. Instead, the function of primary cilia relies on the dynamic composition of molecules within the cilium, the context-dependent sensing and processing of extracellular stimuli, and cycles of assembly and disassembly in a cell- and tissue-specific manner. Thereby, primary cilia dynamically integrate different cellular inputs and control cell fate and function during tissue development. Here, we review the recently emerging concept of primary cilia dynamics in tissue development, organization, remodeling, and function.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Cilia Dynamics ; Ciliary Signaling ; Cilium Disassembly ; Primary Cilia ; Tissue Organization; Protein-coupled Receptors; Bardet-biedl-syndrome; Retinal-pigment Epithelium; Left-right Asymmetry; Planar Cell Polarity; Ift-a Complex; Intraflagellar Transport; Extracellular Vesicles; Leftward Flow; Proteomic Analysis
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 0261-4189
e-ISSN 1460-2075
Zeitschrift EMBO Journal, The
Quellenangaben Band: 42, Heft: 21, Seiten: e113891 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Heidelberg, Germany
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Pancreatic Islet Research (IPI)
POF Topic(s) 90000 - German Center for Diabetes Research
PSP-Element(e) A-502600-001
Förderungen European Research Council
DOI 10.15252/embj.2023113891
WOS ID 001070676500001
Scopus ID 85172013611
PubMed ID 37743763
Erfassungsdatum 2023-10-18
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