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Delbrouck, C.* ; Kiweler, N.* ; Chen, O.* ; Pozdeev, V.I.* ; Haase, L.* ; Neises, L.* ; Oudin, A.* ; Fouquier d'Hérouël, A.* ; Shen, R. ; Schlicker, L.* ; Halder, R.* ; Lesur, A.* ; Schuster, A.* ; Lorenz, N.I.* ; Jaeger, C.* ; Feucherolles, M.* ; Frache, G.* ; Szpakowska, M.* ; Chevigne, A.* ; Ronellenfitsch, M.W.* ; Moussay, E.* ; Piraud, M. ; Skupin, A.* ; Schulze, A.* ; Niclou, S.P.* ; Letellier, E.* ; Meiser, J.*

Formate promotes invasion and metastasis in reliance on lipid metabolism.

Cell Rep. 42:113034 (2023)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Metabolic rewiring is essential for cancer onset and progression. We previously showed that one-carbon metabolism-dependent formate production often exceeds the anabolic demand of cancer cells, resulting in formate overflow. Furthermore, we showed that increased extracellular formate concentrations promote the in vitro invasiveness of glioblastoma cells. Here, we substantiate these initial observations with ex vivo and in vivo experiments. We also show that exposure to exogeneous formate can prime cancer cells toward a pro-invasive phenotype leading to increased metastasis formation in vivo. Our results suggest that the increased local formate concentration within the tumor microenvironment can be one factor to promote metastases. Additionally, we describe a mechanistic interplay between formate-dependent increased invasiveness and adaptations of lipid metabolism and matrix metalloproteinase activity. Our findings consolidate the role of formate as pro-invasive metabolite and warrant further research to better understand the interplay between formate and lipid metabolism.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Cancer Metastasis ; Cp: Cancer ; Cp: Metabolism ; Formate Overflow ; Invasion ; One-carbon Metabolism; Cancer; Acid; Serine
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 2211-1247
e-ISSN 2211-1247
Zeitschrift Cell Reports
Quellenangaben Band: 42, Heft: 9, Seiten: , Artikelnummer: 113034 Supplement: ,
Verlag Cell Press
Verlagsort 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Artifical Intelligence Cooperation Unit (HAICU)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-530001-001
Förderungen
FNR-BRIDGE program
Televie
FNR-INTER program
DFG-fellowship
FNR-ATTRACT program
DOI 10.1016/j.celrep.2023.113034
WOS ID 001093464200001
Scopus ID 85169832515
PubMed ID 37651228
Erfassungsdatum 2023-10-18
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