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Zhao, T. ; Markevych, I.* ; Fuertes, E.* ; de Hoogh, K.* ; Accordini, S.* ; Boudier, A.* ; Casas, L.* ; Forsberg, B.* ; Garcia Aymerich, J.* ; Gnesi, M.* ; Holm, M.* ; Janson, C.* ; Jarvis, D.* ; Johannessen, A.* ; Jörres, R.A.* ; Karrasch, S. ; Leynaert, B.* ; Maldonado Perez, J.A.* ; Malinovschi, A.* ; Martinez-Moratalla, J.* ; Modig, L.* ; Nowak, D.* ; Potts, J.* ; Probst-Hensch, N.* ; Sánchez-Ramos, J.L.* ; Siroux, V.* ; Urrutia Landa, I.* ; Vienneau, D.* ; Villani, S.* ; Jacquemin, B.* ; Heinrich, J.*

Impact of long-term exposure to ambient ozone on lung function over a course of 20 years (The ECRHS study): A prospective cohort study in adults.

Lancet Reg. Health-Eur. 34:100729 (2023)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Background: While the adverse effects of short-term ambient ozone exposure on lung function are well-documented, the impact of long-term exposure remains poorly understood, especially in adults. Methods: We aimed to investigate the association between long-term ozone exposure and lung function decline. The 3014 participants were drawn from 17 centers across eight countries, all of which were from the European Community Respiratory Health Survey (ECRHS). Spirometry was conducted to measure pre-bronchodilation forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) at approximately 35, 44, and 55 years of age. We assigned annual mean values of daily maximum running 8-h average ozone concentrations to individual residential addresses. Adjustments were made for PM2.5, NO2, and greenness. To capture the ozone-related change in spirometric parameters, our linear mixed effects regression models included an interaction term between long-term ozone exposure and age. Findings: Mean ambient ozone concentrations were approximately 65 μg/m³. A one interquartile range increase of 7 μg/m³ in ozone was associated with a faster decline in FEV1 of −2.08 mL/year (95% confidence interval: −2.79, −1.36) and in FVC of −2.86 mL/year (−3.73, −1.99) mL/year over the study period. Associations were robust after adjusting for PM2.5, NO2, and greenness. The associations were more pronounced in residents of northern Europe and individuals who were older at baseline. No consistent associations were detected with the FEV1/FVC ratio. Interpretation: Long-term exposure to elevated ambient ozone concentrations was associated with a faster decline of spirometric lung function among middle-aged European adults over a 20-year period. Funding: German Research Foundation.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Air Pollution ; Forced Expiratory Volume ; Middle Aged ; Ndvi ; Spirometry ; Vital Capacity; Respiratory Health Survey; Follow-up; Pollution
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 2666-7762
e-ISSN 2666-7762
Zeitschrift The Lancet Regional Health - Europe
Quellenangaben Band: 34, Heft: , Seiten: , Artikelnummer: 100729 Supplement: ,
Verlag Elsevier
Verlagsort Radarweg 29, 1043 Nx Amsterdam, Netherlands
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504000-008
G-504000-009
Förderungen German Research Foundation
DOI 10.1016/j.lanepe.2023.100729
WOS ID 001078521700001
Scopus ID 85169614645
PubMed ID 37691742
Erfassungsdatum 2023-10-18
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